Immunopharmacology Flashcards
Immunosuppresant action of cyclosporine
Inhibition of the gene transcription of interleukins
- Inhibits calcineurin
Suppresses cellular inmmunit, inhibits prostaglandin and leukotriene synthesis, and increases the catabolism of IgG antiboides
Prednisone
Chimeric monoclonal antibody that binds to TNF-a and inhibits its action
Infliximab
- Etanercept: chirmeric protein containing portion of the numan TNF-a
What type of immunologic process being triggered by Penicillin
Mediated by IgE
Type I
Which immunologic process is beeing triggered by anti-psychotic drugs
Mediated by IgG and IgM
Type II
Immunosupressant that supresses both B and T lymphocytes via inhibtion of de-novo syntheis of purines
Mycophenolate mofetil
Recombinant IL-2 has proven useful in the treatment of what malignancy
Renal Cell carcinoma
What toxicity is more likely to be seen on sirolimus than with cyclosporine
Thrombocyopenia
Immune modulator that increases phagocytosis by macrophages in patients with chronic granulomatous disease
Interferon-y
Prednisone
Activation of glucocorticoid receptor leads to altered gene transcription
Used in many inflammatory conditions, organ transplantation, and hematologic cancers
DUration of activity is longer than pharmacokinbetic half life of drug owing to gene transcription effect
SE: adrenal suppression, growth inhibition, muscle wasting, osteoporosis, salt retention, glucose intolerance,behavioral changes
Cyclosporine
The complex of cyclosporin-cyclophilin inhibits calcineurin
Used in organ transplantation, GVHD, some autoimmune disease
Metabolized by P450 system. Many drug-drug interactions
SE: renal dysfunction, hypertension, neutotoxicity
Like cyclosporine but inhibits calcineurin by binding to FK506 immunophilin
Tacrolimus
Its binding to cyuclophilil inhibits the IL-2 signalling pathway; toxicity effects include hypertriglyceridemia, hepatotoxicity, diarrhea, and myelosuppression
Sirolimus
Mycophenolate mofetil
Purine antagonist
Blocks de novo GTP synthesis by inhibiting inosine monophosphate dehydrogenase
Organ transplantation, GVHD, some autoimmune disease
Oral, parenteral
SE: GI disturbacnes, myelosuppression
Thalidomide
Complex immune effects including reduction in TNF-a production
USed in erythema nodusum leprosum, multiple myeloma
Oral
SE: teratogen, somnolence, peripheral neuropathy, neutropenia
Thalidomide analog approved for multiple myeloma
Lanalidomide
Alefacept
CD2 receptor antagonus
Binds to T-cell CD2 receptor and blocks is association with LFA-3
Psoriasis
Recombinant protein. Parenteral
SE: reduced T-cell count, hepatotoxicity, hypersensitivity reaction, infection, malignancy-withdrawn from the market
Anakinra
IL-1 antagonists
Usef for rheumatoid arthritis
Daclizumab
IL-2 antagonist
Renal transplantation
chimeric MAb similar to daclizumab
Basiliximab
Mepolizumab
IL-5 anatgonists
Severe eosinophili asthma
Situximab
IL-6 anatgonists
Multicentric Castleman’s disease
Ixekizumab
IL-17 anatgonists
moderate to severe plaque psoriasis
Secukinumab
IL-17
Ustekinumab
Il-12 and 23 anatgonist
Plaque psoriasis
Omalizumab
anti-Ige
Severe asthma
Natalizumab
Anti-integrins
Drug resistant multiple scloris and Chron’s disease
Belimumab
Anti-B cell activating factor
Activem autoantibody-positive SLE
human IgG MAb againist TNF
Golimumab
humanized Fab fragment binds to TNF
Certolizumab
Interferon used for multiple sclerosis
Interferon a-1b
Interferon used for leukemia, melanoma, hepatitis B and C
Interferon a-2a
Interferon used for chronic granulomatous disease
Interferin y-1b
