Pharma 3 final Flashcards

1
Q

True or false
An increase in elimination through the kidney will have the same effects as an increase in in metabolism from the liver

A

FALSE
An increase in kidney elimination will have almost the same effect
It will have reduced cmax reduced tmax reduced area under the curve as well as increased elimination rate
However the therapeutic effect will decrease no matter if the mother or the metabolite are the active substance which is different from the liver

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2
Q

A patient presents with kidney insufficiency
What should we do to their administered drugs and why

A

We should reduce the dose
A kidney insufficiency means a reduction in elimination
Which means that we will have a larger cmax larger T max larger area under the curve smaller elimination rate and overall larger therapeutic effect

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3
Q

And how many doses of continuous medication do we reach the equilibrium

A

Around five or seven

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4
Q

How does a change in clearance affect the time necessary to obtain equilibrium for continuous administration

A

An increase in clearance** decreases the time necessary**
And decrease in clearance** increases the time necessary** and the effect of the drug

page 75

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5
Q

Describe how a change in volume of distribution effects the effect of a drug in continuous administration

A

An increase in volume distribution which can be due to a decrease in plasma protein binding

C Max will lower and cement will lower the average dose will stay the same

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6
Q

Lorsque la vitesse d’absorption d’un médicament est diminuée : (lequel est VRAI)

La pente du déclin des concentrations sanguines est modiiée

La concentration maximale (Cmax) et la surface sous la courbe (SSC) sont diminuées

L’efficacité d’un médicament administré en dose unique n’est jamais affectée

La réponse obtenue à la suite d’une administration multiple d’un médicament n’est pas affectée et le régime thérapeutique (doses et intervalles d’administration) ne nécessite pas d’ajustement

A

La réponse obtenue à la suite d’une administration multiple d’un médicament n’est pas affectée et le régime thérapeutique (doses et intervalles d’administration) ne nécessite pas d’ajustement

Because absorption rate only affects single dose medication

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7
Q

Lorsque le volume de distribution d’un médicament diminue parce que le patient a perdu de la masse adipeuse, cela se fait aux dépens des tissus du compartiment V2, en conséquence : (lequel est VRAI)

Le temps nécessaire pour atteindre Cmax (tmax) est plus long

La surface sous la courbe (SSC) est grandement affectée à la hausse

L’effet maximal (Emax) et la toxicité sont nécessairement diminués

La pente de déclin des concentrations sanguines est augmentée

A

La pente de déclin des concentrations sanguines est augmentée

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