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USMLE > Pharm8 - Pharm8 > Flashcards

Pharm8 - Pharm8 Flashcards

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USMLE® Step 1 flashcards
1
Q

which drugs cause pulmonary fibrosis?

A

busulfan bleomcyin amiodarone

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2
Q

which drugs cause gyneomastia

A

‘Some drugs create awesome knockers’ spironolactone digitalis cimetidine alcoholism ketoconazole (estrogen)

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3
Q

which drugs cause SLE like syndrome

A

‘it’s not HIPP to have lupus’ hydralazine inh procainamide phenytoin

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4
Q

which drugs –> osteoporosis

A

CHO corticosteroids heparin

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5
Q

which drug –> gingival hyperplasia

A

phenytoin

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6
Q

which drugs –> photosensitivity

A

Amy played Tetris on her cell phone in the sun amiodarone sulfonamides tetracycline

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7
Q

which drugs –> tendonitis and tendon rupture in kids

A

fluoroquinolones

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8
Q

which drug –> gray baby syndrome

A

chloramphenicol

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9
Q

which drugs –> agranulocytosis

A

colchicine carbamazepine clozapine

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10
Q

which drugs –> atropine like side effects

A

tricyclics

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11
Q

which drugs –> cardiac toxicity

A

Dawn sat on the Docks mending her red, broken heart doxorubicin daunorubicin

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12
Q

which drugs –> torsades de pointes

A

Ia and III aniarrhytmics cisapride

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13
Q

which drugs –> focal/massive hepatic necrosis

A

Hello Val! Have a seat before your liver dies! halothane valproic acid acetaminophen

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14
Q

which drug –> fanconi’s syndrome

A

expired tetracycline

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15
Q

which drug –> interstitial nephritis

A

methicillin

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16
Q

which drugs –> hemorrhagic cystitis

A

cyclophosphamide ifosfamide

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17
Q

which drug –> hepatitis

A

INH

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18
Q

which drugs –> pseudomembranous colitis

A

I have to take a CLAMP clindamycin ampicillin

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19
Q

which drugs –> nephrotoxicity AND ototoxicity

A

‘if you call, i won’t be able to hear you in the bathroom’ Cisplatin aminoglycoside loop diuretics

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20
Q

which drugs –> seizures

A

buproprion imipenem clistatin

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21
Q

which drugs –> DI

A

lithium demeclocycline

22
Q

which drugs –> aplastic anemia

A

chloramphenicol benzene NSAIDS

23
Q

which drug –> coronary vasospasm

A

cocaine

24
Q

which drugs –> flushing

A

AIDEN was in the VAN FLUSHING NIACIN and CALCIUM niacin CCB adenosine vancomycin

25
Q

which drug –> hemolysis in G6PD pts

A

sulfonamides INH aspirin ibuprofen primaquine nitrofurantoin

26
Q

whch drugs –> acute aholestatic hepatitis

A

macrolides

27
Q

which drugs –> cinchonism

A

quinidine quinine

28
Q

which drugs –> disulfiram like rxn

A

metronidazole some cephalosporins procarbazine sulfonylureas

29
Q

which drug –> neurotoxicity/nephrotoxicty

A

polymyxins

30
Q

uses for cytarabine

A

AML

31
Q

examples of nitrosureas

A

‘you MUST not let the Nitro go to your head, or you’ll do a strip tease- a sin!’ carmustine lmoustine semustine streptozacin

32
Q

uses for nitrosureas

A

brain tumors (incl. GBM)

33
Q

uses of the -platins

A

Platinum treated BOLTs breast ovarian lung testicular

34
Q

uses for busulfan

A

‘I will bustle to treat my dark CaMeL’ CML

35
Q

adverse effects of busulfan

A

‘I will bustle to treat my DARK CaMeL’ hyperpigmentation pulmonary fibrosis

36
Q

uses for rubicins

A

‘MS. Hodgkin’s will LOB the RED ball’ myeloma sarcoma Hodkin’s lung ovarian breast

37
Q

uses for dactinomycin

A

‘children ACT out’ rhabdomyosarcoma wilm’s tumor ewing sarcoma

38
Q

MOA 6MP

A

blocks do novo purine synth, activated by HGPRTase

39
Q

which 2 drugs work synergistically with each other to prevent DNA replicaion?

A

5-FU MTX

40
Q

MOA MTX

A

blocks DHF reductase, preventing DHF –> THF

41
Q

MOA 5FU

A

blocks thymidylate synthase (preventing dUMP –> dTMP)

42
Q

which cancer agen has minimal myelosuppression?

A

bleomycin

43
Q

leucovorin

A

folinic acid that can reverse some of the myelosuppression associated with MTX (doesn’t do anything for 5FU myelosuppression)

44
Q

‘rescue agent’ for 5FU

A

thymidine

45
Q

which cancer agent –> macrovesicular fatty change in liver?

A

MTX

46
Q

cancer agents that alkylate DNA

A

Busulfan Platins Nitrosureas cyclophosphamide/ifosfamide

47
Q

which alkylating agent requires bioactivation

A

nitrosureas

48
Q

uses for -phosphamides

A

non-hodgkin’s breast ovarian

49
Q

which drugs intercalate in DNA?

A

3D doxorubicin daunorubicin dactinomycin

50
Q

which cancer agents generate free radicals

A

doxorubicin daunorubicin bleomycin

USMLE (16 decks)

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