Pharm10 - Pharm10

Question 1

MOA orlistat

Answer 1

inhibits pancreatic lipase

Question 2

clinical use of orlistat

Answer 2

obesity management

Question 3

toxcicity of orlistat

Answer 3

gi discomfort steatorrhea reduced absorption of fat soluble vitamins ha

Question 4

MOA sibutramine

Answer 4

sympathommimetic 5HT and NorE reuptake inhibitor

Question 5

uses of sibutramine

Answer 5

short term and long term obesity management

Question 6

toxicity of sibutramine

Answer 6

htn tachycardia

Question 7

uses of GH

Answer 7

GH deficiency turner’s syndrome

Question 8

uses of somatostatin

Answer 8

acromegaly carcinoid gastrinoma glucagonoma

Question 9

uses of octeroitide

Answer 9

(aka somatostatin) acromegaly carcinoid gastrinoma glucagonoma

Question 10

uses of adh

Answer 10

pituitary DI

Question 11

MOA propylthiouracil

Answer 11

inhibits organification and coupling of thyroid hormone synthesis decreased peripheral conversion of T4 –> T3

Question 12

Which drugs block peptidoglycan cross-linking

Answer 12

Cephalosporin -cillins -nam/-nem

Question 13

which drugs block peptidoglycan synthesis?

Answer 13

bacitracin vancomycin cycloserine

Question 14

which drugs block bacterial/fungal cell wall synth

Answer 14

polymyxins

Question 15

which drugs disrupt fungal cell membranes

Answer 15

amphotericin b nystatin -azoles

Question 16

which drugs block NT synth

Answer 16

‘Try my cell phone - I blocked the New Cleo’ Sulfonamides trimethoprim

Question 17

which drugs block DNA synth

Answer 17

‘TOPless DANcing Queen’ (insert abba song here… :) Topoisomerase Quinolones

Question 18

which drugs block mRNA synth

Answer 18

rifampin

Question 19

Which drugs block protein synth at the 50S subunit?

Answer 19

-mycins linezolid -gramins macrolides chloramphenicol

Question 20

which drugs block protein synth at the 30S subunit

Answer 20

Aminoglycosides tetracyclines

Question 21

MOA penicillin

Answer 21

it binds to penicillin binding proteins blocks the cross-linking of peptidoglycan activates autolytic enzymes

Question 22

uses for penicillin

Answer 22

gram + cocci and rods GNR spirochetes

Question 23

which penicillins are the penicillinase resistant?

Answer 23

Nafcillin dicloxacillin methicillin

Question 24

clinical uses for penicillinase resistant penicillins?

Answer 24

S. aureus (except for MRSA)

Question 25

why are penicillinase resistant penicillins resistant to penicillinase

Answer 25

bulikier R group

Question 26

how is MRSA resistant to methicillin

Answer 26

altered penicillin binding protein target site

Question 27

adverse reaction to methicillin

Answer 27

interstitial nephritis

Question 28

examples of aminopenicillins

Answer 28

ampicillin amoxicillin

Question 29

what is clavulanic acid

Answer 29

penicillinase inhibitor

Question 30

clinical uses for aminopenicillins

Answer 30

'ampicillin/amoxicillin HELPS kill enterococci' H. influenza e. coli Listeria monocytogenes Proteus mirabilis Salmonella Enterococci

Question 31

anti-pseudomonal drugs

Answer 31

'Take Piper in the Car, Sue' ticarcillin piperacillin carbenicillin

Question 32

MOA cephalosporins

Answer 32

same as penicillins, less susceptible to penicillinases

Question 33

uses for 1st generation cephalosporins

Answer 33

PEcK Proteus E coli Klebsiella

Question 34

uses for 2nd generation cephalosporins

Answer 34

HEN PEcKS H. flu Enterobacter Neisseria Proteus E. coli Klebsiella Serratia

Question 35

examples of 1st generation cephalosporins

Answer 35

'You FAILed the FIRST PHASE' cefazolin cephalexin

Question 36

examples of 2nd generation cephalosporins

Answer 36

'Wait a SECOND! You SEE, FOX FUR is a FACt' cefoxitin cefuroxime cefaclor

Question 37

3rd generation cephalosporins

Answer 37

'If you are THIRsty, try a FOTO TAZER' Cefotaxime Ceftazidime ceftriaxone

Question 38

clinical uses of aztreonam

Answer 38

klebsiella pseudomonas serratia (GNR only, nothing against gm + or anaerobes)

Question 39

who is given aztreonam

Answer 39

penicillin allergic pts pts w renal insuff that can't tolerate aminoglycosides

Question 40

what is cilastatin?

Answer 40

inhibits renal dihydropeptidase I always administered with imipenem

Question 41

clinical uses for imipenem/meropenem?

Answer 41

gram + cocci GNR anaerobes

Question 42

toxicity of imipenem, meropenem

Answer 42

gi distress rash seizures (all occcur at high plasma levels)

Question 43

MOA aminoglycosides 'cidal/static?

Answer 43

inhibits formation of initiation complex --> misreads mRNA requires O2 for uptake, so won't work against anaerobes 'cidal

Question 44

which drugs are aminoglycosides?

Answer 44

'Mean GNATS canNOT kill anaerobes' Gentamicin Neomycin Amikacin Tobramycin Streptomycin

Question 45

toxicity of aminoglycosides

Answer 45

'Mean GNATS canNOT kill anaerobes' Nephrotoxicity (esp if used with cephalosporin) Ototoxicity (esp w/ loop diuretic) Teratogen

Question 46

Uses for tetracyclines

Answer 46

VACUUM THe BedRoom Tunight V. cholera Acne Chlamydia Ureaplasma Urealyticum Mycoplasma pneumoniae Tularemia H. Pylori Borrelia Burgodorferi Rickettsia

Question 47

MOA tetracyclines 'cidal/static?

Answer 47

binds 30S and prevents attachment of aminoacyl RNA static

Question 48

foods to avoid when takin tetracyclines

Answer 48

don't take with milk, iron, or antacids b/c it will inhibit absorption in gut

Question 49

which tetracycline is fecally eliminated?

Answer 49

doxycycline (can be used in renal failure)

Question 50

toxicity of tetracyclines

Answer 50

photosensitivity gi discomfort discoloration of teeth inhibits bone growth in kids

Question 51

contraindications of tetracyclines

Answer 51

pregnancy

Question 52

what drug can act as a diuretic in SIADH

Answer 52

demeclocycline (ADH antagonist)