Pharm2 - Pharm2

Question 1

MOA phenytoin

Answer 1

Increases Na channel inactivation

Question 2

MOA carbamazepine

Answer 2

Increases Na channel inactivation

Question 3

MOA lamotrigine

Answer 3

blocks voltage gated Na channels

Question 4

MOA gabapentin

Answer 4

increases GABA release

Question 5

MOA topiramate

Answer 5

Blocks Na channels, increases GABA release

Question 6

MOA phenobarbital

Answer 6

increases GABA

Question 7

MOA valproic acid

Answer 7

increases GABA, blocks Na channels

Question 8

MOA ethosuxamide

Answer 8

blocks ca channels in thalamus

Question 9

MOA benzos

Answer 9

increases GABA

Question 10

uses for phenytoin

Answer 10

everything but absence seizures. status epilepticus prophylaxis

Question 11

usees for lamotrigine

Answer 11

everything but absence and status

Question 12

uses for carbamazepine

Answer 12

everything but absence and status

Question 13

uses for gabapentin

Answer 13

all seizures except absence and status peripheral neuropathy

Question 14

uses for topirimate

Answer 14

everything but absence and status

Question 15

uses for phenobarbital

Answer 15

everything but absence and status

Question 16

uses for valproic acid

Answer 16

everything but status

Question 17

uses for ethosuxamide

Answer 17

absence

Question 18

uses for benzos in epilepsy

Answer 18

acute status

Question 19

which anti-epileptic drugs are 1st line in pregnancy and children

Answer 19

phenobarbital

Question 20

which epi drug is 1st line for trigeminal neuralgia

Answer 20

carbamazepine

Question 21

which drug is used to treat peripheral neuropathy

Answer 21

gabapentin

Question 22

which drug is used to treat myoclonic seizures

Answer 22

valproic acid

Question 23

which drug is used to treat seizures in eclampsia

Answer 23

MgSO4 (1st line) benzos

Question 24

which epileptic drug –> sedation, tolerance, and dependence?

Answer 24

benzos

Question 25

which epileptic drug --> aplastic anemia, liver toxicity, and teratogenesis?

Answer 25

carbamazepine

Question 26

which epileptic drug --> diplopia, ataxia?

Answer 26

carbamazepine phenytoin

Question 27

which epileptic drug --> GI distress, lethargy, headache?

Answer 27

ethosuxamide

Question 28

which epileptic drugs --> stevens johnson syndrome

Answer 28

ethosuxamide lamotragine

Question 29

which epileptic drug --> nystagmus, gingival hyperplasia, hirsutism?

Answer 29

phenytoin

Question 30

which epileptic drug --> SLE like sydnrome

Answer 30

phenytoin

Question 31

which epi drug --> spina bifida and other NTDs

Answer 31

valproic acid

Question 32

which epi drug --> kidney stones

Answer 32

topiramate

Question 33

which epilepsy drug --> malignant hyperthermia?

Answer 33

phenytoin

Question 34

how do you treat OD of barbiturates?

Answer 34

symptom management

Question 35

how do you treat OD of benzos?

Answer 35

flumazenil (competitive antagonist at GABA receptor)

Question 36

other than for epilepsy, what can phenytoin be used for?

Answer 36

anti-arrhythmic

Question 37

which is more dangerous in overdose: benzos or barbiturates?

Answer 37

barbiturates (longer t1/2 and more respiratory/cv depression)

Question 38

MOA l-dopa

Answer 38

l dopa crosses bbb (dopamine doesn't) so it is converted to dopamine by dopa decarboxylase in CNS

Question 39

carbidopa

Answer 39

peripheral decarboxylase inhibitor in order to increase bioavailability in brain and decrease peripheral side effects (since the conversion to dopamine won't occur peripherally)

Question 40

toxicity of l-dopa?

Answer 40

arrhythmias from peripheral conversion of DA dyskinesia following lt admin akinesia between doses

Question 41

MOA selegiline

Answer 41

selectively inhibits MAO-B, increasing availability of DA

Question 42

use of selegiline

Answer 42

adjunctive to l-dopa in parkinsons

Question 43

toxicityy of selegeliene

Answer 43

enhances l-dopa toxicity

Question 44

MOA sumatriptan

Answer 44

5-HT1D agonist --> vasoconstriction

Question 45

use of sumatriptan

Answer 45

acute migraine cluster headache attacks

Question 46

what type of drug is bethanechol?

Answer 46

direct cholinergic agonist

Question 47

what type of drug is carbechol

Answer 47

direct cholinergic agonist

Question 48

what type of drug is pilocarpine

Answer 48

direct cholinergic agonist

Question 49

what type of drug is methacholine

Answer 49

direct cholinergic agonist

Question 50

what is the difference between direct cholinergic agonsts and indirect?

Answer 50

direct directly stimulate cholinergic receptors and indirect inhibit their breakdown via AChE

Question 51

uses of bethanechol

Answer 51

activates bladder and bowel smooth muscle (used post-op for ileus and urinary retention)

Question 52

uses of carbechol

Answer 52

glaucoma pupillary contraction release of intraocular pressure

Question 53

uses of pilocarpine

Answer 53

potent stimulator for saliva, sweat, and tears

Question 54

uses of methacholine

Answer 54

challenge test for asthma dx

Question 55

action of methacholine

Answer 55

stimulates muscarinic receptors in airway

Question 56

class: neostigmine

Answer 56

indirect cholinomimetic

Question 57

class pyrodostigmine

Answer 57

indirect cholinomimetic

Question 58

class: edrophonium

Answer 58

indirect cholinomimetic

Question 59

class: physostigmine

Answer 59

indirect cholinomimetic

Question 60

class: echothiophate

Answer 60

indirect cholinomimetic

Question 61

uses for neostigmine

Answer 61

post-op and neurogenic ileus and uriNAry retention MG reversal of NM junction blockade

Question 62

uses for pyridostigmine

Answer 62

MG

Question 63

uses for edrophonium

Answer 63

to dx MG

Question 64

uses for physostigmine

Answer 64

glaucoma and atropine OD

Question 65

uses for echothiophate

Answer 65

glaucoma

Question 66

which indirect ACh agonist penetrates CNS

Answer 66

physostigmine