Pharm-Staph/Strep

Question 1

Daptomycin MOA

Answer 1

Lipopeptide that disrupts cell membranes via rapid membrane depolarization and K+ efflux

Question 2

Dapto cidal static?

Answer 2

Cidal

Question 3

Dapto ADME?

Answer 3

1x/day IV infusion, NEVER IM injection
Serum-bound
Renal elim

Question 4

Dapto AEs?

Answer 4

Muscle pain/weakness (IM injection toxic) - monitor CK elevation

Caution when co-ad with statins

Question 5

Daptomycin coverage/uses?

Answer 5

Aerobic G+ inc MRSA VRSA enterococcus
MRSA and MSSA abcteremia

do NOT use dapto for pneumonia

Question 6

Oxazolidinones MOA

Answer 6

Inhibit protein synth via 50S binding

Question 7

Oxazolidinones cidal static?

Answer 7

Static for Staph and enterocci

Cidal for strep

Question 8

Linezolid resistance?

Answer 8

Some S aureus and enterococcus

Question 9

Linezolid indications?

Answer 9

Reserve for serious VRE
MRSA and resistant S epi
Enterococcus

Question 10

Linezolid ADME

Answer 10

Oral/parenteral
100% oral abs, food delays but not diminish
Elim renal and non - no dose adj

Question 11

Linezolid AEs?

Answer 11

Mild; diarrhea, HA, N/V

if therapy > 2 wks:
myelosuppression
neuropathy inc optic

Question 12

This drug contains aspartame and as a result PKU pts should be warned

Answer 12

linezolid

Question 13

Linezolid C/Is and interxns

Answer 13

MAOI: MAO inhibitor

Hypertension?

Question 14

Synercid is made of?

Answer 14

Dalfopristin and quinupristin

Question 15

Streptogramins MOA

Answer 15

Inhibit protein synthesis via binding peptidyltransferase and blocking tRNA synthesis and AA addition to peptide chain

Question 16

Clindamycin MOA

Answer 16

Inhibit 50S

Do not give with erythromycin or won’t work

Question 17

Clindamycin static cidal?

Answer 17

conc dep

Question 18

Mupirocin MOA

Answer 18

Inhib protein and RNA synthesis by binding tRNA synthetase

Question 19

Mupirocin spectrum

Answer 19

G+ G_
Staph, strep, MRSA
Can be topical for impetigo
Elim MRSA carriage by healthcare workers

Question 20

Mupirocin AEs

Answer 20

Vehicle can cause renal failure (PEG)

Question 21

Bacitracin MOA

Answer 21

Polypeptide cell wall synth inhibitor - no depilation of carrier protein

Question 22

Bacitracin spectrum

Answer 22

G+ cocci and bacilli

Question 23

Bacitracin AEs

Answer 23

Severely nephrotoxic if parenteral