Pharm-Staph/Strep Flashcards
Daptomycin MOA
Lipopeptide that disrupts cell membranes via rapid membrane depolarization and K+ efflux
Dapto cidal static?
Cidal
Dapto ADME?
1x/day IV infusion, NEVER IM injection
Serum-bound
Renal elim
Dapto AEs?
Muscle pain/weakness (IM injection toxic) - monitor CK elevation
Caution when co-ad with statins
Daptomycin coverage/uses?
Aerobic G+ inc MRSA VRSA enterococcus
MRSA and MSSA abcteremia
do NOT use dapto for pneumonia
Oxazolidinones MOA
Inhibit protein synth via 50S binding
Oxazolidinones cidal static?
Static for Staph and enterocci
Cidal for strep
Linezolid resistance?
Some S aureus and enterococcus
Linezolid indications?
Reserve for serious VRE
MRSA and resistant S epi
Enterococcus
Linezolid ADME
Oral/parenteral
100% oral abs, food delays but not diminish
Elim renal and non - no dose adj
Linezolid AEs?
Mild; diarrhea, HA, N/V
if therapy > 2 wks:
myelosuppression
neuropathy inc optic
This drug contains aspartame and as a result PKU pts should be warned
linezolid
Linezolid C/Is and interxns
MAOI: MAO inhibitor
Hypertension?
Synercid is made of?
Dalfopristin and quinupristin
Streptogramins MOA
Inhibit protein synthesis via binding peptidyltransferase and blocking tRNA synthesis and AA addition to peptide chain
Clindamycin MOA
Inhibit 50S
Do not give with erythromycin or won’t work
Clindamycin static cidal?
conc dep
Mupirocin MOA
Inhib protein and RNA synthesis by binding tRNA synthetase
Mupirocin spectrum
G+ G_
Staph, strep, MRSA
Can be topical for impetigo
Elim MRSA carriage by healthcare workers
Mupirocin AEs
Vehicle can cause renal failure (PEG)
Bacitracin MOA
Polypeptide cell wall synth inhibitor - no depilation of carrier protein
Bacitracin spectrum
G+ cocci and bacilli
Bacitracin AEs
Severely nephrotoxic if parenteral
