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OS Derm > Pharm-Antifungals > Flashcards

Pharm-Antifungals Flashcards

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Dermatology Board Prep flashcards
1
Q

Therapy for widespread tinea

A

Oral only

Terbinafine > itraconazole > fluconazole > griseofulvin

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2
Q

Therapy for localized tinea

A

Topical azoles, terbinafine, naftifine, ciclopirox

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3
Q

Onchomycosis oral therapy?

A

Terbinafine, griseofulvin, itraconazole, fluconazole

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4
Q

Onchomycosis topical therapy?

A

Ciclopirox, amorolfine

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5
Q

Ciclopirox MOA

A

Blocks fungal tmem tport, depleting substrates and int w nucleotide synthesis

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6
Q

Ketoconazole AEs

A

Notoriously hepatotoxic
Adrenal insufficiency
CYP interactions

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7
Q

Itraconazole AEs

A

Negative inotropic action: HF, vent dysfunction, co-administrations
Hepatotoxicity: monitor LFTs
CYP
C/I post-partum and pregnancy

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8
Q

Flu Pos Vori AEs

A

CYP
QT
Hepatotoxic

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9
Q

Vori unique AEs

A

visual disturbances

photosensitivity

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10
Q

Posaconazole ADME

A

must be given with full meal or carbonated drink

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11
Q

Which azoles can be used in pregnant patients?

A

NONE

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12
Q

Fluconazole ADME

A

Renal elim - dose adj necessary

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13
Q

Which azoles penetrate the CSF?

A

Fluconazole > voriconazole

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14
Q

Griseofulvin ADME

A

Cannot penetrate skin - never topical

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15
Q

Griseofulvin AEs

A

CYP inducer: Anticoags, contraceptives, cyclosporine, EtOH
Photosensitivity
C/I: preg, hepato, porphyria

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16
Q

Which azole has potential cross-reactivity with penicillins?

A

Griseofulvin (with penicillin, cephs, and carbapenems)

17
Q

Terbinafine AEs

A

Few, get CBCs

C/I immunosuppression

18
Q

Naftifine MOA

A

Squalene 2,3 epoxidase inhibitor somehow blocks ergosterol synthesis
Interacts with azoles

19
Q

Ciclopirox ADME AE

A

Topical only

Hypersensitivity

20
Q

Amorolfine MOA

A

inhibits ergosterol synthesis

21
Q

Amorolfine ADME AEs

A

Topical only, hypersensitivity possible

OS Derm (20 decks)

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