Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

OS Derm > Pharm-Skin Cancer > Flashcards

Pharm-Skin Cancer Flashcards

You may prefer our related Brainscape-certified flashcards:
Dermatology Board Prep flashcards
1
Q

Carmustine indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cisplatin indication

A

Basal, squamous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cyclophosphamide indication

A

basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cyclophosphamide indication

A

basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Dacarbazine indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dactinomycin indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

docetaxel indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Doxorubicin indication

A

basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Fluorouracil indication

A

basal, actinic keratosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

lomustine indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MTX indication

A

basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Vinblastine indication

A

Basal, melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Aldesleukin indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

diclofenac indication

A

ak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

imiquimod indication

A

basal, ak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

interferon indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

ipilimumab indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

sorefenib indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

trametinib indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

trichloroacetic acid indication

A

ak

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

vemurafenib indication

A

melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

vismodegib indication

A

basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Which drug is most likely to be used against SCC?

A

Cisplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Most drugs are used for these cancers

A

BCC and melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Most popular chemo drug for SCC?

A

cisplatin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Most popular chemo drugs for melanoma?

A

D drugs (exc doxo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Describe the treatment algorithm of basal cell carcinoma

A

1) Topical 5-FU or Imiquimod

2) Cisplatin chemo for metastases and Vismodegib (HH) targeted therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Imiquimod MOA

A

TLR7 and 8 activator and adenosine blockage that upregulates Nf-kB -> cytokine up regulation (immunostimulant)

ALSO HH pathway repression by modulating “GLI”

29
Q

Imiquimod is also used for these non-cancers

A

AK, HPV

30
Q

Imiquimod route

A

topical, limited systemization

31
Q

Imiquimod AEs

A

Photosensitivity, compromised birth control when used for HPV

32
Q

HH pathway inhibitors target this protein

A

Smoothened (SMO)

33
Q

HH pathway goes awry most commonly in this skin cancer

A

Basal

34
Q

Vismodegib MOA

A

SMO inhibitor

35
Q

Vismodegib AEs

A

3 BLACK BOX WARNINGS:
Intrauterine fetal death
Male-mediated teratogenicity
Pregnancy

alopecia, GI common

36
Q

Which drug does NOT act as a teratogen?

A

Imiquimod

37
Q

Describe the treatment for squamous cell carcinoma?

A

Surgery/radiation, not drugs; Cisplatin-based regimen for metastatic/advanced disease

38
Q

Describe the different drug modalities and their comparative effectivness in treating melanoma

A

Conventional chemo - bad ~7%
Immunotherapy - better but very toxic
Signal transduc inhibitors - best, BRAF mut target

39
Q

What are the signal transduction inhibitors used in melanoma?

A

Sorafenib, trametinib, vemurafenib

40
Q

Aldesleukin MOA

A

IL-2 receptor binder -> proliferation of B and T cells, monos, macros, and CTLs inc NK

41
Q

Aldesleukin black box warnings

A

CNS, cardiac, pulmonary disease

42
Q

IL-2 activation drawback

A

Also stimulates Tregs which diminish benefits

Can cause capillary leak syndrome

43
Q

IFN-alpha MOA

A

RTK activation->antiviral, antiproliferative, cytokine induction, HLA expression…

44
Q

IFN-alpha C/Is bbw

A

Autoimmune, cardiac disease, depression (suicidal ideations)

45
Q

IFN common AEs

A

Flu-like, leukopenia, anemia
Liver issues
Pulmonary issues

46
Q

Ipilimumab MOA

A

Stimulate T cell function by binding CTLA4, a T cell repressor (cytotoxic lymphocyte-associated antigen)

It’s an “indirect” action on melanoma?

47
Q

Ipilimumab serious AEs

A

Severe immune-mediated AEs inc dermatitis and toxic necrolysis;

MANY BBWS: adrenal, hepatitis, hyperthryoid, hypopituitary, hypoT, MG, peri neurop, preg, rash

48
Q

Ipilimumab common AEs

A

Fatigue, diarrhea, itching, rash

49
Q

Sorafenib MOA

A

Multikinase inhibitor:
VEGF, PDGFR, KIT, RAFK

Blocks both 1)proliferative and 2)angiogenic signaling

50
Q

Sorafenib AEs

A

Severe rash, hepatic dys, hematologic

Common: hand/foot, anemia, rash

Prego - cat D

fatal bleeding possible

51
Q

Combining these two drugs demonstrated increased progress-free survival in melanoma patients but not overall survival

A

Dacarbazine plus sorafenib

52
Q

Which drugs require genotyping?

A

Trametinib and vemurafenib (for BRAF, for melanoma)

53
Q

Trametinib MOA

A

MEK inhibitor for patients with BRAF V600E or V600K mutations

54
Q

Trametinib AEs

A

Severe skin toxicity in 12%
GI, diarrhea
Dec LVEF!, HTN, Hemorrhage

Rarely: cardiomyopathy, ILD, EYE stuff

55
Q

Both of these drugs block MEK

A

Trametinib and Vemurafenib

56
Q

How does resistance develop to BRAF targeted drugs?

A

Proliferative signaling by a parallel, unaffected pathway

E.g., RAS-driven proliferation

57
Q

Vemurafenib Aes

A

Inc risk of cutaneous SCC
Liver, cardiac, EYE

Most common: arthralgia, fatigue, rash, photosensitivity

58
Q

Describe the common toxicity profile for BRAF inhibitors

A 
RASH
Liver
Heart
Eye
2ndary maligs
59
Q

Carmustine MOA

A

Alkylation and carbamoylation of amino acids

60
Q

Dactinomycin MOA

A

DNA intercalator

61
Q

Lomustine MOA

A

alkylating agent

62
Q

Carmustine AEs

A

myelosuppression

63
Q

Dacarbazine AE

A

myelosuppression

64
Q

Dactinomycin AE

A

Myelosuppression

65
Q

Which drugs are used for actinic keratosis?

A

5-FU, Imiquimod
Diclofenac - PGE2 inhibitor
Tri-Chlor - peel

all are topical so no systemic toxicity

66
Q

Diclofenac MOA

A

Inflammation inhib inc PGE2

67
Q

Diclofenac AEs

A

Itchy rash, dry skin, peeling, redness

68
Q

Trichlor MOA

A

Chemical peel that penetrates and cauterizes skin and keratin

69
Q

Trichlor AEs

A

burning, inflammation, tenderness

OS Derm (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions