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OS Derm > Pharm-Acne/Psoriasis > Flashcards

Pharm-Acne/Psoriasis Flashcards

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Dermatology Board Prep flashcards
1
Q

The mAbs for psoriasis target what?

A

TNF alpha

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2
Q

compare the administration of the monoclonal antibodies for psoriasis

A

infliximab is IV, others are SC

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3
Q

Infliximab absolute contraindications

A

HF

Murine sensitivity

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4
Q

Etanercept absolutely contraindications

A

sepsis

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5
Q

BBWs for mAB antipsoriatics

A

Infection
Neoplasia
TB
Immunosuppressive therapy or vaccination

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6
Q

Ustekinumab MOA

A

binds p40 required for IL-12 and Il-23 activation

suppresses Th1 and Th17 cells

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7
Q

Ustekinumab AEs

A

Infection, neoplasia
Virus vaccination C/I (live)
Test for TB first
Anaphylaxis

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8
Q

Retinoids MOA

A

Activate RAR/RXR in suprabasal keratinocytes to upregulate basal keratinocyte proliferation, thickening epidermis and more flaking of stratum corneum

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9
Q

RAR vs RXR activation effects?

A

RAR: cell differentiation/proliferation (tretinoin)
RXR: induce apoptosis (mycosis fungoides use)

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10
Q

Retinoids AEs

A

Similar to vit A intoxication, dry skin, nosebleeds, conjunctivitis, reduced night vision, hair loss

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11
Q

Retinoids labs

A

Get lipids, transams, CBC, pregnancy tests

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12
Q

Are retinoids teratogens

A

yes all ORAL retinoids

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13
Q

isotretinoin specific AE

A

depression/suicidal ideation

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14
Q

RAR-selective retinoids AEs

A

mucocutaneous & M/S

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15
Q

RXR-selective retinoids AEs

A

physiochemical changes

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16
Q

Calcipotriene MOA

A

Binds vit D receptor; assoc with RXR and binds DNA vit D response elements

17
Q

Calcipotriene AEs

A

Topical irritation

Hypercalcemia with XS dose

18
Q

Calcitrol vs calcipotriene?

A

Calcitrol better tolerated for sensitive areas

19
Q

Benzoyl peroxide MOA

A

Prodrug converted to free radical that is lethal for P acnes

20
Q

Describe the absorption of corticosteroids regionally

A

Varies widely; scrotum > forehead > palm > plantar foot etc

21
Q

Where should you apply fluorinated topical steroids?

A

NOT the face

22
Q

Salicylic Acid MOA

A

desquamation of horny layer of skin

OS Derm (20 decks)

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