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OS Derm > Pharm-Hair & Misc > Flashcards

Pharm-Hair & Misc Flashcards

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Dermatology Board Prep flashcards
1
Q

Minoxidil MOA

A

Unknown, vasodilation

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2
Q

Minoxidil AEs

A

Minor, skin irritation, etc

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3
Q

Finasteride MOA

A

T analog that blocks 5-a-reductase, reducing scalp and serum DHT concentrations

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4
Q

Finasteride AEs

A

Libido loss, sexual dys-ED, feminization

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5
Q

Saw palmetto MOA is like this drug

A

Finasteride - block 5-a-reductase so less T

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6
Q

Eflornithine MOA

A

Dec ornithine decarboxylase activity -> less cell division and differentiation

Effect takes 6-8 wks

Also works against trypanosomes (sleeping sickness)

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7
Q

Eflornithine AEs

A

Face and chin only; rare adverse skin events

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8
Q

Fluocinolone MOA

A

Anti-inflammatory corticosteroid that reduces facial skin darkening

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9
Q

Hydroquinone MOA

A

Inhibits melanin formation by blocking tyrosine oxidation to dopamine

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10
Q

Tretinoin MOA

A

Modulates skin growth/pigmentation - inc keratinocyte shedding from epidermis

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11
Q

Fluocinolone, hydroquinone, tretinoin AEs

A

Sensitive to UV

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12
Q

Methoxsalen MOA

A

Activated by UVA exposure -> cross-linking of DNA -> cell death

Delayed erythema after weeks then increased epidermal melanization and stratum corneum thickening

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13
Q

Methoxsalen indications

A

Vitiligo, relief of psoriasis, mycosis fungicides, alpecia areata, dermatoses, eczema, lichen planus

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14
Q

Chemo-induced alopecia target

A

NOT the bulge, the stem cell source for hair

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15
Q

Scalp cooling - is it beneficial?

A

Potentially; banned though

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16
Q

Scalp cooling - concerns?

A

Vasoconstriction may indeed inhibit drug penetration of scalp, but micrometastases in the scalp thus become unchecked by the chemo

Also clearance issues for pts with renal/hepatic dysfunction

17
Q

Eflornithine indication

A

reduce unwanted female facial hair

18
Q

Is eflornithine a depilatory agent?

A

No

OS Derm (20 decks)

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