Pathophys-Day 1 Skin Structure & Function

Question 1

What cells types are active after skin damage?

Answer 1

Keratinocytes in epidermis and fibroblasts in dermis

Question 2

What is responsible for thermoregulation of the skin?

Answer 2

Vasculature of dermis

Question 3

Photoprotection cells?

Answer 3

Melanocytes

Question 4

Atopic dermatitis is primarily a defect of the __ function of the skin

Answer 4

barrier

Question 5

Bullous pemphigoid - pathogenesis

Answer 5

autoantibodies to basement membrane hemidesmosomes between epidermis and dermis

Question 6

Pemphigus vulgaris pathogenesis

Answer 6

autoantibodies to desmosomes within the epidermis

Question 7

Hydrohidrotic ectodermal dysplasia pathogenesis

Answer 7

Genetic - mutant EDAR gene (ectodysplasin A receptor) critical for interaction between developing ectoderm and mesoderm

Question 8

Hydrohidrotic ectodermal dysplasia presentation

Answer 8

Abnormal hair follicles, sweat glands, and teeth

overheat easily from not sweating

Question 9

Antiphospholipid antibody syndrome skin appearance

Answer 9

Widespread necrosis (big black islands)

Question 10

trigeminal trophic syndrome ?

Answer 10

loss of sensation to face causes excessive scratching leading to sloughing (severe) of skin