Pharm- Opiods Flashcards
Morphine- Indications
Severe pain, gold standard opiate.
Morphine- MOA
Blocks substance P, alters perception of pain, centrally acting
Morphine- AE
Constipation, respiratory depression
Hydromorphone- Indication
Severe pain! Better for patients with renal impairment
Hydromorphone-MOA
Inhibits substance P, binds to opioid receptors
Hydromorphone-AE
constipation, resp. depression, addiction
Tylenol with Codeine- Indications
Moderate to severe pain, antitussive
Tylenol with Codeine- MOA
Acetaminophen- inhibits prostaglandin synthesis, pain impulse
Codeine- Binds to opiate receptors, inhibits ascending pain pathway, suppresses cough
Tylenol with Codeine- AE
Resp. depression, dizziness, caution in renal & hepatic impairment
Hydrocodone- Indications
Moderate to severe pain
Hydrocodone- MOA
Converted to morphine in liver- blocks opioid receptors.
Hydrocodone- AE
CNS depression, constipation
Oxycodone- Indications
Moderate to severe pain
Oxycodone- MOA
Semisynthetic derivative of morphine
Oxycodone- AE
Resp depression, constipation, increased intracranial pressure
Meperidine- Indications
Acute pain, short term use
Meperidine- MOA
Binds to Mu receptors, different than morphine. Synthetic
Meperidine- AE
Anxiety, tremors, muscle twitch, lower seizure threshold
Methadone- Indications
Chronic pain management, withdrawal from opioids due to long life
Methadone- MOA
Strong agonis- binds to mu and NMDA receptor increasing duration of effects.
Methadone- AE
Euphoria, hypotension, liver & renal failure
Tramadol- Indications
Mild & neuropathic pain
Tramadol- MOA
Weak agonist, inhibits uptake of neurotransmitters, CNS inhibition
Tramadol- AE
Seizures, anxiety, N/V, sedation
