Pemphigus Vulgaris

Question 1

Buzzwords?

Answer 1

. Flaccid blisters → rupture easily & form painful erosions
Suprabasal split
Oral lesions seen

Question 2

Name the commonest variant?

Answer 2

Pemphigus vulgaris

Question 3

Trapper?

Answer 3

P . Foliaceus → superficial bulla → subcorneal split( i.e. in the granular layer or just below stratum corneum )
in seborrheic distribution
No oral lesions

Question 4

Auto antigens against?

Answer 4

Dsg3
+ dsg1 - in patients with skin involvement

Question 5

Associations?

Answer 5

HLA-DR4
DRW6

Question 6

Immunofluorescance pattern?

Answer 6

IgG deposits - fishnet pattern

Question 7

Histology?

Answer 7

Suprabasal - spinous cell layer

Question 8

Describe the features of pemphigus foliaceus ?

Answer 8

Auto ag - dsg 1
Split - granular subcorneal
Direct if- IgG
Asso - drugs, thymoma, myasthenia gravis
Presenting features- crusts & shallow erosions on scalp, central face, chest & back