Atopic Dermatitis

Question 1

Hint & buzzwords !

Answer 1

Itchy rash on the face of this infant + family h/0 asthma

Question 2

What is the genetic correlation between dermatitis & respi . symptoms showing up together?

Answer 2

Dermatitis & asthma are inherited through separate though closely related genetic pathways

Question 3

Family history looks like??

Answer 3

H/0→ asthma, hay fever or dermatitis

Question 4

Pathology?

Answer 4

Increased → Ig E synthesis
→ serum IgE
→ specific IgE to food, aero allergens, bacteria & bacterial products
Increased CD23 expression low affinity IgE receptor) on monocyte & b cells
Impaired → delayed type hypersensitivity reactions

Question 5

Criteria?

Answer 5

Hanifin & Rajka criteria
3 major 3 minor should be present

Question 6

Pruritus & scratching made worse by?

Question 7

Associated with?

Question 8

Describe the clinical phases of atopic dermatitis

Answer 8

Infantile phase
Childhood phase
Adult phase

Question 9

Differential diagnosis of dermatitis (eczema) in children & adults

Answer 9

Atopic dermatitis
Seborrheic dermatitis
Contact dermatitis
Nummular eczema