Cutaneous Lymphoma

Question 1

Mc type of primary cutaneous lymphoma

Answer 1

Primary cutaneous T-cell lymphoma

Question 2

Mc type of primary cutaneous t-cell lymphoma

Answer 2

Mycosis fungoides

Question 3

Mc type of primary cutaneous B cell lymphoma

Answer 3

Primary cutaneous follicle centra lymphoma > marginal zone lymphoma

Question 4

Marginal zone lymphoma → pathology?

Answer 4

Diffuse or nodular infiltrates of→ small lymphocytes
→ lymphoplasmacytoid cells
→ plasma cells
In dermis
Typically spares epidermis

Question 5

MZL → neoplastic cells?

Answer 5

CD79+
CD19+
CD20+
CD5-,10-

Question 6

MZL → features?

Answer 6

Solitary or multiple papules & nodules
Location → trunk & extremities
DX → flow cytometry
On peripheral smear → small nuclei & abundant cytoplasm with “shaggy” “villous” projection
Treatment → radiotherapy ,
immune therapies in disseminated lesions → IFN -alpha & il-2, mab against CD20