Patterning of dorso-ventral axis Flashcards
1
Q
Where are BMPS expressed?
A
Surface ectoderm cells
2
Q
What do BMPS induce?
A
Neural plate border cells
Roof plate cells
3
Q
What do BMPs do?
A
Induce expression of -Pax6, Pax7, Pax3- cause cells to acquire dorsal identities
4
Q
Where is Shh expressed?
A
The notochord and prechordal mesoderm
5
Q
What does Shh induce?
A
Floor plate cells
6
Q
What does Shh do?
A
Ventralising the neural tube
7
Q
What are class 1 genes?
A
Pax7, Dbx1, Dbx 2 etc.- suppressed and confined to the dorsal part of the neural tube by Shh
8
Q
What are class 2 genes?
A
Nkx6.1, Nkx2.2 etc.- turned on (derepressed) as a result of class 1 genes being repressed
