Myogenesis Flashcards

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1
Q

How do somitic cells become committed to form muscle?

A

Expression of Pax3 and Pax7

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2
Q

What change occurs when myoblasts differentiate into myotubules?

A

They become bipolar in shape and fuse together to form multinucleate myotubules

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3
Q

What are the members of the Myogenic Regulatory Factors family?

A

MyoD
MRF4
Myf5
Myogenin

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4
Q

What turns on the expression of the MRF family? And where are they expressed?

A

Pax3

Muscle precursors and muscle cells

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5
Q

Where is MRF4, MyoD and Myf5 expressed?

A

Proliferating, undifferentiated myogenic cells

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6
Q

Where is Myogenin expressed?

A

Non dividing, differentiated cells

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7
Q

What do the somites form?

A

1.Cartilage
2.Tendons
3.Skeletal muscle
5.Dermis
(and vertebrae!)

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8
Q

What are the 2 myotome domains?

A

Epaxial (medial)

Hypaxial (lateral)

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9
Q

What is required to generate myoblasts?

A

MyoD or or Myf5

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10
Q

What is required for muscle differentiation?

A

Myogenin

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11
Q

What do the mesenchymal cells of the limb bud secrete?

A

Hepatocyte growth factor/ scatter factor

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12
Q

What do the limb muscle progenitor cells express?

A

Pax3 induces the expression of the receptor c-met- binds to HGF/SF

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13
Q

What do satellite cells express when they differentiate?

A

MyoD and Myf5

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