Morphogens Flashcards
1
Q
What are 2 important characteristics of morphogens?
A
- They induce different fates at different concentrations
2. They act directly at a distance
2
Q
What is restrictive diffusion?
A
When the signal binds to the extracellular matrix- helps create a more steep concentration gradient
3
Q
What are heparon sulphate proteoglycans?
A
Receptors found in the ECM that bind to many ligands- including morphogens
They can slow diffusion
4
Q
What is the transcriptional read out model?
A
The higher the concentration of morphogen, the higher the amount of activated transcription factor
5
Q
What is genetic cross-talk regulation?
A
When the activation of one gene produces a repressor which blocks the expression of another gene
