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Advanced developmental biology > iPSCs > Flashcards

iPSCs Flashcards

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1
Q

How many T. factors in a ‘cocktail’ can induce pluripotency?

A

4

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2
Q

What are the advantages of iPSCs?

A
  1. No embryo needed
  2. Can get individual specific cells- personalised
  3. Vastly renewable
  4. Easily accessible
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3
Q

What are the obstacles in the therapeutic application of iPSCs in humans?

A
  1. Use of viral vectors for gene delivery carries the risk of insertional mutagenesis- tumourigenicity
  2. Low efficiency and SLOW kinetics of reprogramming cells
  3. Lack of robust and reliable differentiation protocols for human iPS cells
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4
Q

What are the key 4 transcription factors?

A

Oct4
Sox2
cMyc
Klf4

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Advanced developmental biology (26 decks)

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