Pathoma Cervix Flashcards

1
Q

Where does cervical cancer usually happen?

A

transformation zone between the squamous epithelium of exocervix and single layer columnar on endocervix

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2
Q

Condyloma

A

HPV. cancer and stuff from it, if you have questions about HPV, see the vuvla cards

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3
Q

What are the two cancer proteins in HPV?

A

E6 knocks out p53, so no checking DNA before S phase and BAX isn’t activated.

E7 destroys Rb, which holds E2F until. If Rb is destroyed, E2F goes buckwild

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4
Q

Briefly, how do you grade cervical intraepithelial neoplasm?

A

CIN I is 1/3 of thickness of epithelium (reversible 66% of time)

CIN II is 2/3 of thickness (33% reversible)

CIN IIIis almost the entire epithelium (unlikely to reverse)

Carcinoma is insitu is entire thickness and not reversible

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5
Q

What are risk factors for cervical carcinoma?

A

HPV, immunodeficiency. SMOKING. Smoking is bad, it causes it, no way to really understand why, just don’t forget it (similar to how smoking causes pancreatic cancer for unknown mechanism)

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6
Q

What is most common cause of death from cervical cancer?

A

Blocks ureter and hydronephrosis causing renal failure

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7
Q

What do you look for in a pap smear?

A

Dysplasia. A high nucleus:cytoplasm ratio with dark nucleus

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8
Q

What type of cancer does a pap smear find?

A

Squamous cell carcinoma, not good for adenocarinoma (which HPV can also cause)

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9
Q

What is ASCUS, ASC-H, LSIL, HSIL?

A

Pap results.

Atypical squamous cells of undetermined significance

Atypical squamous cells can’t exclude high grade dysplasia

Low grade squamous intraepithelial lesions consistent with HPV. CIN2 or worse in 12%

HSIL is high grade squamous intraepithelial lesions. Often CIN2 or CIN3. Sometimes carcinoma

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10
Q

When do you need to do ECC with coop?

A

ASC-H or worse

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11
Q

What do you do with ASCUS?

A

HPV test, if positive do colposcopay, if negative, it is normal epithelial change and no worries.

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12
Q

More than 90% of invasive squamous cervix are people who don’t do screening

A

oh thats sad

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13
Q

What is vaccination good for?

A

5 years on 6, 11, 16, 18

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14
Q

What are nobathian cysts?

A

endocervical gland mucus retention cyst

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