Female incontinence; 4.15 Flashcards
What kind of androgen receptors are found in the bladder dome?
Beta-receptors
What is the effect of having beta-receptors in the bladder dome when sympathetics are active?
The bladder relaxes…this is the case while STORING urine
What kind of androgen receptors are found at the bladder neck (internal urinary sphincter)?
Alpha-receptors
What is the effect of having alpha-receptors in the bladder neck when sympathetics are firing?
The sphincter constricts…this would also be necessary while STORING urine
Where else are alpha-receptors in the urinary system?
The urethra…again, sympathetics would cause the urethra to constrict so the bladder won’t leak
Besides sympathetic activity, what else is going on during urine storage?
Cholinergics are inhibited
What nerve sends the sympathetic control to the bladder?
Hypogastric nerve
What nerve sends the cholinergic activity?
Pudendal nerve
What are some lifestyle modifications that can be made to treat stress incontinence?
Weight loss
Fluid retention
Smoking cessation
What can be done to strengthen the pelvic floor?
Kegel exercises
Electrical stimulation
Biofeedback
Extracorporeal magnetic innervation
What are devices that can be used to occlude the urethra?
Pessary
Urethral inserts
What are some meds that can be used to treat stress incontinence, despite not being approved?
Intravaginal estrogen
Duloxetine
Alpha-adrenergic drugs
Why is estrogen given intravaginally?
Because it would WORSEN the condition if it was given SYSTEMICALLY
What is the problem with duloxetine?
Duloxetine has more side effects
Are alpha-adrenergics commonly used?
No…alpha-adrenergics are not commonly used