Pathology of the Cardiovascular System Pt 2 Flashcards
What species is hypertrophic cardiomyopathy common in?
Hypertrophic cardiomyopathy is most common in cats
What species is dialated cardiomyopathy common in?
- Dilated cardiomyopathy is most common in dogs, especially in young to middle-age dogs of giant or large
breeds.
What breeds have an increased susceptibility to dialated cardiomyopathy?
Saint Bernard, Great Danes, Irish Wolfhounds, Doberman
pinschers, Portuguese Water dogs etc., have an increased susceptibility (familial pattern).
What is seen in this image? What are some key features indicating this pathology?
Dilated cardiomyopathy
Characteristics: Rounded and enlarged heart, ventricles dilated.
What is the condition seen in this image? What is important to note about this condition?
wall not very thickened
Characteristic eccentric hypertrophy, increased number of sarcomeres which increases size overall/ dilation, not the muscle itself.
What is seen in this image? What animal is this likely from?
Likely a cat since this is hypertrophic cardiomyopathy.
What is seen with the left ventricle in this image? What will this cause?
Left ventricular enlargement with thickening of the left ventricular wall. But ventricular chambers are smaller. Eventually there will be ischemia and necrosis and then will cause CHF.
What weight indicates hypertrophy?
Anything above 20 grams
In cardiac hypertrophy, what other area will be enlarged along with the left ventricle?
L Atrium
What is seen in this image?
Enlarded heart with enlarged left ventricle and atrium
What is indicated by the blue and green circles in this image?
Blue circle -> narrowed.ventricle from hypertrophy
Green circle -> areas of pallor/ necrosis. Ischemic damage of cardiac myocytes.
Area is huge now and heart has issues trying to fill it all.
What is seen in this image?
Cat HCM. Cardiomyocytes exhibit variable degrees of hypertrophy and are often arranged in an interweaving rather than parallel pattern. Cardiomyocyte nuclei are variable in size and there is myocardial disarray. Image below is normal cardiomyocytes.
What is the likely cause of these signs?
Saddle Thrombus ,
ATE
What signs are seen with Saddle thrombus?
ATE -> cats seem fine and then are not. They will be painful, have an enlarged heart, congestion, ect. Saddle thrombus.
What is seen in this image?
What is the issue with this heart in this image? The heart also weighs 38.9 grams. Is that normal or abnormal?
What is seen in this image? Where are these thrombi usually found?
Thrombus at the bifurcation of the abdominal aorta into the external iliac arteries (“Saddle thrombus” Aorto-iliac thrombosis). Can develop thrombus in the left atrium, or bifurcation of terminal aorta
What signs are seen with Saddle thrombus?
-> no pulse in femoral artery
-> cold legs ( poor perfusion)
-> Severe pain
-> respiratory distress.
What percent of cats with cardiac hypertrophy may present with ATE?
20-30%
What is myocarditis? What is it often a result of?
Blood coming from aorta is more susceptible to developing thrombosis.
Often the result of an hematogenous infection
* Viral- Covid 19, canine parvovirus, foot and mouth, encephalomyocarditis in elephants, ect
* Bacterial
* Parasitic (Protozoan: Toxoplasmosis, sarcocystosis, neosporosis, encephalitozoonosis, trypanosoma cruzi…; Metazoan: Cysticercosis, trichinosis)…
What is seen in this image? What is the likely causeative agent and why?
What is seen in this image? What is the likely causative agent?
What is seen in this image? What is indicated with the blue curcle? What is indicated with the green?
What is the usual cause of abcesses in the heart of cattle?
H. Somni
What is seen in this image? What is the likely cause?
Is cysticercosis zoonotic?
yes
What is the larval stage of taneia ( platyhelminth, tapeworms?
cysticercus
Where does the adult stage of taneia reside? What about the larval stage?
The adult stage is in the intestine of the definite host (humans,
dogs, wild carnivores). The larval stage (cysticercus) is in the
muscle of the intermediate host (pigs, cattle, moose, reindeer
etc.,).
What causes cysticercosis in humans? What happens if you eat cysticerci?
Cysticercosis in humans (including neurocysticercosis) is
the result of ingestion of taenia eggs, not from ingestion of
cysticerci. Ingestion of cysticerci by consumption of raw or
incompletely cooked pork completes the cycle: formation of the
tapeworm in the intestine.
What is seen in these images? What is circled in blue? What happens if these lesions are seen in the slaughterhouse?
Cystercercosis in skeletal muscle/ heart of a pig
vesicles contain scolex of taniea ( in this case taenia solium)
These animals are condemned in the slaughter house.
What are the primary cardiac neoplasias? Are they benign or malignant?
Rhabdomyoma -> Benign
* Rhabdomyosarcoma -> Malignant
* Schwanomma -> Schwann cells in cattle
* Hemangiosarcoma ->
Right atrium in dogs sometimes. Can cause hemopericardium/ tamponade
* Heart base tumors (usually aortic body tumors
[chemodectoma] – less often tumors arising from ectopic thyroid or parathyroid tissue)
Whar are the secondary cardiac neoplasias?
Metastatic tumors, including LSA –specially cattle.
What is seen in this image? Is it common?
Right atrial hemangiosarcoma is quite common.
What is seen in this image?
Hemangiosarcoma -> Tumor emboli which cause secondary tumors in the lung due to metastasis.
What should you consider if you see nodular cystic structures on the heart that is filled with blood?
Consider hemangiosarcoma
What is seen in this image?
Atrial Hemangiosarcoma.
What is seen in this image? What can it be confused with? What must you do to determine what it is?
Chemodectoma -> need to do testing to r/o that its not ectopic thyroid/ parathyroid.
What is seen in these images?
Chemodectoma
What is seen in this image? If I tell you this is a cow heart, what is the likely cause of this condition?
any malignant tumor can metastasize to the heart but lymphosarcomas are common.