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Hematology And Oncology > Pathologic RBC forms > Flashcards

Pathologic RBC forms Flashcards

1
Q

Macro-ovalocytes RBCs - seen in

A
  1. megaloblastic anemia (also hypersegmented cells)

2. marrow failure

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2
Q

elliptocyte RBCs - seen in

A

hereditary elliptocytosis

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3
Q

bite cells - also called

A

degmacytes

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4
Q

bite cells RBCs - seen in

A

G6PD deficiency

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5
Q

Ringed sideroblasts RBCs - seen in

A

sideroblastic anemia

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6
Q

ringed sedrerblasts RBCs - mechanism

A

Excess iron in mitochrondria

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7
Q

scistocytes RBCs - seen in

A
  1. DIC 2. HELLP syndrome 3. TTP/HUS

4. mechanical hemolysis (heart valve prosthesis)

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8
Q

scistocytes RBCs - also called

A

helmet cells

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9
Q

Basophilic stippling RBCs - seen in

A
  1. Lead poisoning
  2. sideroblastic anema
  3. Myelodisplastic syndromes
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10
Q

Acanthocytes RBCs - also called

A

spur cell

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11
Q

Acanthocytes RBCs - seen in

A
  1. liver disease

2. abetalipoproteinemia (states of cholesterol dysregulation)

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12
Q

Target RBCs - seen in

A
  1. HbC disease 2. asplenia

3. Liver disease 4. Thalassemia

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13
Q

Teardrop RBCs - seen in

A

bone marrow infiltration (eg. myelofibrosis)

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14
Q

Teardrop RBCs - also called

A

Dacrocytes

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15
Q

Spherocytes RBCs - seen in

A
  1. Hereditary spherocytosis

2. drugs and infection induced hemolytic anemia

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16
Q

Sickle cells RBCs - seen in

A

sickle cell anemia

17
Q

sickle cell anemia - sickling occurs with

A
  1. dehydration
  2. deoxygenation
  3. high altitude
18
Q

Howell-Jolly bodies - seen in

A
  1. asplenia

2. functional hyposplenia

19
Q

Howell-Jolly bodies - mechanism

A

Basophilic nuclear remnants found in RBCs.

Normally removed from RBCs by splenic macrophages

20
Q

Heinz bodies - seen in

A
  1. G6PD deficiency

2. Heinz body - like inclusions in α-thalassemia

21
Q

Heinz bodies - mechanism

A

Oxidation of HB-SH groups to S-S –> Hb precipitation (Heinz bodies) –> phagocytic damage to RBC membrane –> bite cells

22
Q

hereditary elliptocytosis - presentation

A

usually asymptomatic

23
Q

hereditary elliptocytosis - mechanism

A

mutation in gene encoding RBC membrane proteins (eg. spectrin)

24
Q

Echinocytes vs acanthocytes according to image

A

Echinocytes projection are more uniform and smaller

25
Q

Echinocytes - seen in

A
  1. end-stage renal disease
  2. liver disease
  3. pyruvate kinase

Hematology And Oncology (21 decks)

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