Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Hematology And Oncology > Lymphomas > Flashcards

Lymphomas Flashcards

1
Q

leukemia vs lymphoma: leukemia

A

lymphoid or myeloid neoplasm with widespread involvement of bone marrow. Tumor cells are usually found in peripheral blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

leukemia vs lymphoma: lymphoma

A

Discrete tumor mass arising from lymph nodes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Leukemoid reaction

A

Acute inflammatory response to infection. Increased WBC cound with increased neutrophils and neutrophil precursors such as band cells (left shift)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hodgkin - strongly associated with

A

EBV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

non-Hodgkin - may be associated with

A
  1. HIV

2. autoimmune diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

lymphoma - Constitutionals Β signs/symptoms

A
  1. low grade fever
  2. night sweats
  3. weight loss
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Hodgkin vs non-Hodgkin lymphoma - Constitutionals Β signs/symptoms

A

common in Hodgkin

not common in Non-Hodgkin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Hodgkin - age

A

bimodal distribution - young adulthood and >55 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

non-Hodgkin lymphoma - age

A

Peak incidence for certain subtypes at 20-40 years old

CAN OCCUR IN CHILDREN AND ADULTS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Hodgkin lymphoma - men or women

A

more common in men except for nodular sclerosing type

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Hodgkin lymphoma - cells

A

Reed-Sternberg cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

non-Hodgkin lymphoma - cells

A 
B cells
T cells (fewer)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

non-Hodgkin lymphoma - location

A

Multiple, peripheral nodes, extranodal involvement common, noncontaguous spread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hodgkin lymphoma - location

A

Localized, single group of nodes. Extranodal rare. Contiguous spread.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Hodgkin vs non-Hodgkin lymphoma - prognosis

A

prognosis is much better in Hodgkin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Hodgkin vs non-Hodgkin lymphoma - stage is stronger predictor of prognosis

A

Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Reed-Sternberg cells - seen in

A

Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Reed-Sternberg cells - definition

A

distinctive tumor giant cell seen in Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Reed-Sternberg cells - histology

A

binucleate or bilobed with the 2 halves as mirror image (owl eyes)
CD15+ CD30+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Reed-Sternberg cells - positive CD

A

CD15+ CD30+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Reed-Sternberg cells - origin

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Reed-Sternberg cells for hodgkin diagnosis

A

necessary but not sufficient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Hodgkin lymphoma - mechanims for better prognosis

A

strong stromal or lympocytic reaction against Reed-Sternberg cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

MC Hodgkin lymphoma

A

Nodular sclerosing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Hodgkin lymphoma with best prognosis
lymphocyte-rich
26
Hodgkin lymphoma with best prognosis with the worse prognosis
1. lymphocyte mixed | 2. depleted forms
27
Non-Hodgkin lymphoma - divided to
1. Lymphomas of mature B cells | 2. Lymphomas of mature T cells
28
Non-Hodgkin lymphoma B cells - types
1. Burkitt lymphoma 2. Diffuse large B-cell lymphoma 3. Follicular lymphoma 4. Mantle cell lymphoma 5. Primary central nervous system lymphoma 6. Marginal zone lymphoma
29
Burkitt lymphoma - occurs in (age)
adolescents or young adults
30
Burkitt lymphoma - genetics
t(8;14) - translocation of c-myc (8) and heavy - chain Ig (14)
31
Burkitt lymphoma - histology
starry sky appearance, sheets of lymphocytes with interspersed "tingible body" macrophages
32
Burkitt lymphoma - associated with
EBV
33
Burkitt lymphoma - forms
``` endemic form (africa) sporadic form ```
34
Burkitt lymphoma - endemic form
jaw lesion
35
Burkitt lymphoma - sporadic form
pelvis or abdomen lesion
36
MC type of Non-Hodgkin lymphoma
Diffuse large B-cell lymphoma
37
Diffuse large B-cell lymphoma - occurs in (age)
usually older adults but 20% in chidren
38
Diffuse large B-cell lymphoma - adults or children
usually older adults but 20% in chidren
39
Follicular lymphoma - occurs in (age)
adults
40
Follicular lymphoma - genetics
t(14;18) - translocation of heavy-chain Ig (14) and BCL-2 (18)
41
BCL-2 action
inhibits apoptosis
42
Follicular lymphoma presents with
painless waxing and waning lymphadenopathy (indolent course)
43
Follicular lymphoma - histology
follicular architecture: small cleaved cells (grade 1) large cells (grade 3) mixture (grade 2)
44
Mantle cells lymphoma - occurs in
older males
45
Mantle cells lymphoma - marker/presentation
CD5+ | patiens typically present with late stage disease (very aggressive)
46
Mantle cells lymphoma - genetics
t(11:14) - translocation of cycle D1 (11) and heavy-chain Ig (14)
47
Non-Hodgkin lymphoma T cells - types
1. Adults T-cells lymphoma | 2. Mycosis fungoides/Sezary syndrome
48
Adults T-cells lymphoma - occurs in
adults
49
Adults T-cells lymphoma is caused by
HTLV (associated with IV drug abuse)
50
HTLV - transmission (associated with)
IV drug abuse
51
Adults T-cells lymphoma - symptoms
1. cutaneous lesions 2, Lytic bone lesions 3. Hypercalcemia
52
Adults T-cells lymphoma - population
1. Japan 2. West Africa 3. Caribbean
53
Mycosis fungoides/Sezary syndrome - occurs in
adults
54
Mycosis fungoides present with
skin patches/plaques (cutaneous T-cell lymphoma)
55
Mycosis fungoides - histology
atypical CD4+ cells with cerebriform nuclei
56
Mycosis fungoides may progress to
Sezary syndrome (T-cell leukemia)
57
Primary central nervous system lymphoma - T or B cells
B
58
Primary central nervous system lymphoma is associated with
HIV/AIDS (nmz me EBV) B
59
Primary central nervous system lymphoma is considered as
AIDS-defining illness
60
Primary central nervous system lymphoma - presentation
variable: confusion, memory loss, seizures
61
Primary central nervous system lymphoma - appearance (relevance)
Mass lesion(s) on MRI --> needs to be distinguished from toxoplasmosis via CSF analysis or other lab tsts
62
Marginal zone lymphoma - definition
neoplastic proliferation of small B cells (cd20) that expands the marginal zone
63
Marginal zone lymphoma - associated with
chronic inflammatory states such as Hashimoto, Sjogren, H. Pylori MALTOMA is marginal zone of mucosal sites

Hematology And Oncology (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions