embryology Flashcards

1
Q

fetal erythropoiesis occurs in (and when)

A
  1. yolk sac (3-8 weeks)
  2. Liver (6 weeks - birth)
  3. Spleen (10-28 weeks)
  4. Bone marrow (18 weeks to adult)
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2
Q

hemoglobin development - embryogenic globins

A

ζ and ε

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3
Q

hemoglobin development - fetal hemoglobin

A

HbF (α2γ2)

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4
Q

hemoglobin development - adult hemoglobin

A

HbA1 (α2β2)

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5
Q

HBF is the fetal hemoglobin because (relative function)

A

HbF has higher affinity for 02 due to less avid binding of 2,3-BPG allowing HbF to extract 02 from maternal hemoglobin (HbA1 and HbA2) across the placenta

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6
Q

hemoglobin development - α starts approximately at

A

3 weeks (and platue at 12)

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7
Q

hemoglobin development - γ starts approximately at

A

3 weeks –> platue at 12 –> decrease at 35

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8
Q

hemoglobin development - β starts approximately at

A

3 weeks –> platue at 12 weeks after pregnancy

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9
Q

HbA2

A

α2δ2

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10
Q

fetal erythropoiesis occurs in (and when)

A
  1. yolk sac (3-8 weeks)
  2. Liver (6 weeks - birth)
  3. Spleen (10-28 weeks)
  4. Bone marrow (18 weeks to adult)
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