embryology Flashcards
fetal erythropoiesis occurs in (and when)
- yolk sac (3-8 weeks)
- Liver (6 weeks - birth)
- Spleen (10-28 weeks)
- Bone marrow (18 weeks to adult)
hemoglobin development - embryogenic globins
ζ and ε
hemoglobin development - fetal hemoglobin
HbF (α2γ2)
hemoglobin development - adult hemoglobin
HbA1 (α2β2)
HBF is the fetal hemoglobin because (relative function)
HbF has higher affinity for 02 due to less avid binding of 2,3-BPG allowing HbF to extract 02 from maternal hemoglobin (HbA1 and HbA2) across the placenta
hemoglobin development - α starts approximately at
3 weeks (and platue at 12)
hemoglobin development - γ starts approximately at
3 weeks –> platue at 12 –> decrease at 35
hemoglobin development - β starts approximately at
3 weeks –> platue at 12 weeks after pregnancy
HbA2
α2δ2
fetal erythropoiesis occurs in (and when)
- yolk sac (3-8 weeks)
- Liver (6 weeks - birth)
- Spleen (10-28 weeks)
- Bone marrow (18 weeks to adult)