Lab values in anemia, Leukopenias, left shift

Question 1

iron deficiency anemia - iron status

Answer 1

1. low serum iron (1ry)
2. high transferrin or TIBC
3. low ferritin
4. very low trasnferrin saturation (serum iron/TIBC)

Question 2

chronic disease anemia - iron statis

Answer 2

1. low serum iron
2. low trasnferrin or TIBC
3. high ferritin (primary)
4. normal saturation

Question 3

hemochromatosis - iron status

Answer 3

1. high serum iron (primary)
2. low trasnferrin or TIBC
3. high ferritin
4. very high trasnferrin saturation

Question 4

pregnancy/OCP use - iron status

Answer 4

1. serum iron normal
2. trasnferin or TIBC increased (primary)
3. ferritin normal
4. trasnferrin saturation low

Question 5

neutropenia - cell count

Answer 5

less than 1500 cells/mm3

Question 6

neutropenia - severe infections when

Answer 6

less than 500

Question 7

causes of neutropenia

Answer 7

1. Sepsis/postinfection
2. drugs (including chemotherapy)
3. aplastic anemia
4. SLE
5. radiation

Question 8

lymphopenia - cell count

Answer 8

lymphocytes less than 1500 (3000 in children)

Question 9

causes of lymphopenia

Answer 9

1. HIV
2. DiGeiorge
3. SCID
4. SLE
5. corticosteroids
6. radiation
7. sepsis
8. postoperative

Question 10

eosinopenia - cell count

Answer 10

les than 30 cells/mm3

Question 11

causes of eosinopenia

Answer 11

Cushing syndrome

corticosteroinds

Question 12

corticosteroids effects on neutrophils, eosinophils and lymphocytes (and mechanism)

Answer 12

1. neutrophilia –> decrease activation of neutrophil adhesion molecules, imparing migration out of the vasculature at the site of inflammation
2. lymphopenia –> apoptosis
3. eosinopenia –> sequester in lymph nodes

Question 13

Left shift?

Answer 13

increased neutrophil precursor, such as band cells and metamyelocytes

Question 14

left shift usually seen with

Answer 14

neutrophilia in the acute response to infection or inflammation

Question 15

Leukoerythroblastic reaction?

Answer 15

left shift with immature RBCs

Question 16

Leukoerythroblastic reaction - occurs in

Answer 16

1. severe anemia (physiologic response)

2. marrow response (eg. fibrosis, tumor taking up space in marrow)