Path: Skin Lesions and Autosomal Dominant Flashcards
Mulloscum contageosum is caused by what virus?
Pox virus
Impetigo is caused by what type of bacteria?
Gram+, probably Staph
T/F: Type 1 and Type 2 HSV can infect the mouth.
True
Type 1 is more common in mouth
Type 2 mostly in genitals
What is the best way to test for HSV?
Tzanck assay
Where does HSV lie dormant?
Sensory nerve ganglia (esp. trigeminal)
What is the go to antiviral for herpes?
Acyclovir
Middle easterner presents with mouth sores. Patient also has ulcers in eyes and genitals. Diagnosis?
Buhcet’s
What are the ABCDs to think about with malignant melanoma?
- Asymmetry
- irregular Border
- odd Colors
- large Diameter
T/F: Superficial spreading melanoma has the worst prognosis.
False
Nodular melanoma - raised area with deepest penetration
In which phase can metastasis take place with melanomas?
Vertical phase
T/F: Basal cell carcinoma has a very high metastasis rate.
False
Very low metastasis but very common
What is the precursor lesion to squamous cell carcinoma?
Actinic keratosis
T/F: Squamous cell cancer can metastasize.
True
Where is squamous cell cancer found in the epidermis?
Stratum spinosum
T/F: Down’s syndrome is the most common chromosomal disorder.
True
What are some complications of Down’s (trisomy 21)?
- Infection
- Leukemia
- Alzheimer’s
What is the genotype of a patient with Klinefelter syndrome?
XXY
What is the genotype of a patient with Turner syndrome?
XO
T/F: A Turner syndrome patient would experience primary amenorrhea.
True
No periods
T/F: Peutz-Jeghers syndrome is an autosomal dominant disorder.
True
T/F: Peutz-Jeghers syndrome increases the risk of GI cancer.
False
Hemartomatous polyps in the GI tract are an indicator of which autosomal dominant disorder?
Peutz-Jeghers syndrome
Which lesions are associated with cafe au lait spots?
- Neurofibromatosis type 1
- McCune-Albright
- Tuberous sclerosis
- Fanconi anemia
What is the triad for Neurofibromatosis Type 1 (Von Recklinghausen’s Disease)?
- Cafe au lait spots
- Neurofibromas
- Lisch nodules in eye
What is a major complication of Marfan’s syndrome?
Aortic problems
Super long arms/legs
T/F: Marfan’s syndrome is autosomal dominant.
True
T/F: Huntington’s Chorea is autosomal dominant.
True
T/F: Familial polyposis presents a 100% chance of developing colon cancer.
True
T/F: Those with polyps all throughout the intestine have Gardner syndrome.
True
T/F: Gardner syndrome can present with osteomas in the jaw.
True
Osteogenesis imperfecta involves interrupted synthesis of what type of collagen?
Type 1
What deformity in the eye can be from osteogenesis imperfecta?
Blue Sclera
What is the most common type of anemia?
Iron deficiency
Either from nutrition deficiency or blood loss
What type of anemia would result in a positive direct Comb’s test?
Autoimmune anemia (IgG mediated)
