Path: Skin Lesions and Autosomal Dominant

Question 1

Mulloscum contageosum is caused by what virus?

Answer 1

Pox virus

Question 2

Impetigo is caused by what type of bacteria?

Answer 2

Gram+, probably Staph

Question 3

T/F: Type 1 and Type 2 HSV can infect the mouth.

Answer 3

True

Type 1 is more common in mouth

Type 2 mostly in genitals

Question 4

What is the best way to test for HSV?

Answer 4

Tzanck assay

Question 5

Where does HSV lie dormant?

Answer 5

Sensory nerve ganglia (esp. trigeminal)

Question 6

What is the go to antiviral for herpes?

Answer 6

Acyclovir

Question 7

Middle easterner presents with mouth sores. Patient also has ulcers in eyes and genitals. Diagnosis?

Answer 7

Buhcet’s

Question 8

What are the ABCDs to think about with malignant melanoma?

Answer 8

1. Asymmetry
2. irregular Border
3. odd Colors
4. large Diameter

Question 9

T/F: Superficial spreading melanoma has the worst prognosis.

Answer 9

False

Nodular melanoma - raised area with deepest penetration

Question 10

In which phase can metastasis take place with melanomas?

Answer 10

Vertical phase

Question 11

T/F: Basal cell carcinoma has a very high metastasis rate.

Answer 11

False

Very low metastasis but very common

Question 12

What is the precursor lesion to squamous cell carcinoma?

Answer 12

Actinic keratosis

Question 13

T/F: Squamous cell cancer can metastasize.

Answer 13

True

Question 14

Where is squamous cell cancer found in the epidermis?

Answer 14

Stratum spinosum

Question 15

T/F: Down’s syndrome is the most common chromosomal disorder.

Answer 15

True

Question 16

What are some complications of Down’s (trisomy 21)?

Answer 16

1. Infection
2. Leukemia
3. Alzheimer’s

Question 17

What is the genotype of a patient with Klinefelter syndrome?

Answer 17

XXY

Question 18

What is the genotype of a patient with Turner syndrome?

Answer 18

XO

Question 19

T/F: A Turner syndrome patient would experience primary amenorrhea.

Answer 19

True

No periods

Question 20

T/F: Peutz-Jeghers syndrome is an autosomal dominant disorder.

Answer 20

True

Question 21

T/F: Peutz-Jeghers syndrome increases the risk of GI cancer.

Answer 21

False

Question 22

Hemartomatous polyps in the GI tract are an indicator of which autosomal dominant disorder?

Answer 22

Peutz-Jeghers syndrome

Question 23

Which lesions are associated with cafe au lait spots?

Answer 23

1. Neurofibromatosis type 1
2. McCune-Albright
3. Tuberous sclerosis
4. Fanconi anemia

Question 24

What is the triad for Neurofibromatosis Type 1 (Von Recklinghausen’s Disease)?

Answer 24

1. Cafe au lait spots
2. Neurofibromas
3. Lisch nodules in eye

Question 25

What is a major complication of Marfan’s syndrome?

Answer 25

Aortic problems

Super long arms/legs

Question 26

T/F: Marfan’s syndrome is autosomal dominant.

Answer 26

True

Question 27

T/F: Huntington’s Chorea is autosomal dominant.

Answer 27

True

Question 28

T/F: Familial polyposis presents a 100% chance of developing colon cancer.

Answer 28

True

Question 29

T/F: Those with polyps all throughout the intestine have Gardner syndrome.

Answer 29

True

Question 30

T/F: Gardner syndrome can present with osteomas in the jaw.

Answer 30

True

Question 31

Osteogenesis imperfecta involves interrupted synthesis of what type of collagen?

Answer 31

Type 1

Question 32

What deformity in the eye can be from osteogenesis imperfecta?

Answer 32

Blue Sclera

Question 33

What is the most common type of anemia?

Answer 33

Iron deficiency

Either from nutrition deficiency or blood loss

Question 34

What type of anemia would result in a positive direct Comb’s test?

Answer 34

Autoimmune anemia (IgG mediated)