Path-Pancreas

Question 1

final common pathway for pathogenesis of acute pancreatitis

Answer 1

premature activation of digestive enzymes within acinar cells

Question 2

gross features of acute pancreatitis

Answer 2

swollen, more firm than usual, pale; areas of fat necrosis and hemorrhage on outside

Question 3

clinical triad for chronic pancreatitis

Answer 3

diabetes, steatorrhea, radiologic calcifications

Question 4

late stage gross features of chronic pancreatitis

Answer 4

shrunken and fibrotic, cystic dilation of pancreatic ducts

Question 5

microscopic features of chronic pancreatitis

Answer 5

chronic inflammation and fibrosis, loss of tissue, duct dilation, cyst formation, inspissated secretions

Question 6

best way to distinguish chronic pancreatitis from pancreatic adenocarcinoma

Answer 6

chronic pancreatitis preserves overall lobular architecture

Question 7

85-95% of all pancreatic neoplasms are?

Answer 7

invasive ductal adenocarcinoma

Question 8

presentation of ductal adenocarcinoma of pancreas

Answer 8

weight loss, abdominal/back pain, painless jaundice

Question 9

usual microscopic pattern of ductal adenocarcinoma

Answer 9

proliferation of glandular structures, lined by malignant cells within a fibrous stroma; arranged haphazardly (loss of lobular architecture)

Question 10

___ and ___ invasion are common with pancreatic adenoCA

Answer 10

perineural and vascular