Drugs-GI Neuro

Question 1

NTs that modulate the enteric nervous system

Answer 1

serotonin, VIP, CGRP, 5-HT & substance P

Question 2

motor, sensory, and secretory gut functions are controlled by?

Answer 2

bidirectional communication between CNS and ENS

Question 3

gastric stasis, constipation, and bowel obstruction trigger release of?. Which act on the chemoreceptor trigger zone, and then the vomiting center

Answer 3

dopamine, serotonin

Question 4

5-HT4-R agonist and dopamine-R antagosist that augments gastric and small bowel motility

Answer 4

metoclopramide

Question 5

side-effects of metoclopramide

Answer 5

lip smacking, ticks

Question 6

this 5-HT4-R agonist increases LES tone and augments coordinated duodenal contractions and gastric emptying

Answer 6

cisapride

Question 7

cisapride is no longer used routinely due to?

Answer 7

cardiotoxicity with P450 inhibitors

Question 8

how do macrolides effect the GI tract?

Answer 8

motilin-R agonists that augment gastric and SB motility

Question 9

this drug exhibits “tachyphylaxis”

Answer 9

macrolides

Question 10

this drug blocks 5-HT3 at multiple sites leading to suppression of N/V with minimal side effects

Answer 10

ondansetron

Question 11

these dopamine-R antagonists inhibit dopaminergic stimulation of the CTZ

Answer 11

metoclopropramide & domperidome (D2-R)

Question 12

this drug prevents vomiting and gives you the “munchies”

Answer 12

dronabinol (cannabinoid-R agonist)

Question 13

this drug blocks H1 receptors and is used for vomiting in pregnancy

Answer 13

antihistamine, such as promethazine (fenergin)

Question 14

this anti-diarrhetic is an opioid that stimulates enteric but not central mu-opioid receptors

Answer 14

loperamide

Question 15

side effects of loperamide

Answer 15

toxic megacolon, especially if used for c diff/UC

Question 16

this anti-diarrhetic is an opioid that stimulates both enteric and CNS mu-opioid receptors, and is thus combined with atropine to limit abuse

Answer 16

diphenoxylate (combined = Lomotil)

Question 17

this drug is primarily used to treat choleraic diarrhea and as an adjuct for c diff

Answer 17

cholestyramine

Question 18

MoA of cholestyramine

Answer 18

anion exchange resin that binds bile acid and some toxins; poorly absorbed and interferes with absorption of other meds