Path-Esoph Neoplasms

Question 1

two major malignancies of GI tract

Answer 1

squamous cell carcinoma; adenocarcinoma

Question 2

histological features of squamous cell carcinoma

Answer 2

nests/cords of atypical squamous cells +/- keratin pearls, in desmoplastic stroma

Question 3

histological features of adenocarcinoma

Answer 3

overexpansion of glands; look for dark masses with lumens

Question 4

what are the three morphologies that most GI malignancies take?

Answer 4

fungating (=exophytic), infiltrating (through wall), and/or ulcerating (excavation)

Question 5

which is more common: adeno or squamous cell carcinoma of the esophagus?

Answer 5

adenocarcinoma

Question 6

most common location of adenocarcinoma

Answer 6

lower 1/3 of esophagus

Question 7

almost all adenocarcinomas arise from?

Answer 7

Barrett’s epithelium

Question 8

etiologies of squamous cell carcinoma

Answer 8

EtOH, tobacco, esophageal dz, blacks have higher risk

Question 9

most common location of squamous cell carcinoma

Answer 9

any 1/3 of esophagus

Question 10

both squamous cell and adenocarcinoma of the esophagus can grow circumferentially, leading to?

Answer 10

stenosis and dysphagia

Question 11

complications of esophageal malignancy include?

Answer 11

local infiltration, nodal mets, visceral mets