Path-IBD

Question 1

signs of active colitis

Answer 1

cryptitis, crypt abscess, ulceration

Question 2

signs of chronic colitis

Answer 2

altered crypt architecture (dysarray, dropout, branching), inflammation in lamina propria

Question 3

chronic active colitis is?

Answer 3

chronic colitis + neutrophils

Question 4

normal lamina propria has (lowest/highest) inflammatory cell density at crypt bases

Answer 4

lowest

Question 5

inflammatory cells that participate in chronic inflammation of lamina propria

Answer 5

lymphocytes, plasma cells, eosinophils

Question 6

in chronic colitis, there are increased inflammatory cells at?

Answer 6

the base of crypts

Question 7

common to have periods of exacerbation and remission

Answer 7

UC, CD (both)

Question 8

increases risk of colon cancer

Answer 8

UC, CD (both)

Question 9

gross features of UC (2 things)

Answer 9

pseudopolyps, hemorrhagic mucosa

Question 10

wide superficial ulcers seen in ____; deep narrow ulcers seen in _____

Answer 10

UC; CD

Question 11

fissures, fistulas, and fat wrapping are all seen in ____ because it is?

Answer 11

Crohn’s; transmural

Question 12

3 microscopic features that distinguish CD from UC

Answer 12

1. variable involvement, 2. transmural inflammation, 3. +/- granulomas

Question 13

gross appearance of CD (6 things)

Answer 13

skip lesions, cobblestoning, linear ulcers, fissures, fistulas, fat wrapping

Question 14

how do you diagnose IBD?

Answer 14

you must correlate biopsy findings WITH clinical hx and endoscopic findings (each alone is insufficient)