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Gastrointestinal > Clinic-IBD > Flashcards

Clinic-IBD Flashcards

1
Q

colon only

A

UC

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2
Q

focal and patchy

A

CD

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3
Q

transmural inflammation

A

CD

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4
Q

occurs in smokers

A

CD

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5
Q

diffuse and contiguous

A

UC

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6
Q

can present with perianal sx, fistulas, and/or granulomas

A

CD

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7
Q

both UC and CD are more prevalent in the (North/South)

A

North

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8
Q

age of onset for IBD

A

15-30

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9
Q

females are more likely to get this one

A

CD

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10
Q

whites and jewish more likely to get this one

A

UC

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11
Q

associated with chromosome 16 mutation (NOD2)

A

CD

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12
Q

smoking may have a protective effect for this one

A

UC

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13
Q

appendectomy may be protective for this one

A

UC

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14
Q

incidence of IBD peaks at what two points in life

A

20, 50

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15
Q

IBD is more prevalent in the developing/developed world

A

developed

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16
Q

theory behind IBD

A

overly aggressive T cell response directed against environment and/or commensal bacteria

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17
Q

chronic inflammation in IBD is due to an imbalance between?

A

pro- and anti-inflammatory mediators

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18
Q

dysbiosis

A

both

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19
Q

hygeine hypothesis of IBD

A

increase hygeine = decreased development of immune system as child = imbalance between Th1 and Treg cells

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20
Q

genetics associated with CD relate to?

A

microbe recognition, innate immune system

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21
Q

genetics associated with UC relate to?

A

HLA genes, intestinal barrier integrity

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22
Q

____ allelic variants seen in 27-39% of CD pts, confers worse dz and earlier onset

A

NOD2

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23
Q

role of NOD2 protein

A

recognition of microbes and innate immunity

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24
Q

extra-intestinal manifestations of IBD occur in? (4 places)

A

skin, liver, eyes, joints

25
Q

70% of CD involves what part of the intestines?

A

ileum

26
Q

clinical presentation of crohn’s (6 things)

A

abdominal pain, diarrhea, weight loss, growth retardation, fever, perianal dz

27
Q

SBFT of CD shows?

A

high grade strictures (inflammation in bowel)

28
Q

CT of CD shows?

A

thickened wall

29
Q

linear ulcers in SB sign of?

A

CD

30
Q

skip lesions

A

CD

31
Q

2 major complications of CD

A

obstruction, fistulas (abscesses)

32
Q

signs of obstruction

A

cramps, distension, vomiting

33
Q

removal of the terminal ileum may cause?

A

B12 deficiency, bile salt diarrhea, fat malabsorption if >100cm

34
Q

clinical presentation of UC (6 things)

A

bloody diarrhea, tenesmus, crampy abdominal pain with BM, weight loss, fever, growth retardation

35
Q

if concerned about UC, always do an X-ray to rule out?

A

toxic megacolon

36
Q

UC is dx by?

A

sigmoidoscopy or colonoscopy

37
Q

___ increases risk of colorectal cancer (significant risk by ___ years after diagnosis)

A

UC; 30 (screen at 10 years)

38
Q

___ (from last exam) is a risk factor for colorectal ca in pts with UC

A

PSC

39
Q

surgical tx of UC

A

proctocolectomy (koch pouch or ileal pouch anal anastomosis)

40
Q

skin disorders in IBD

A

erythema nodosum, pyoderma gangrenosum, cutaneous CD

41
Q

MSK disorders in IBD

A

peripheral arthritis, sacroileitis (central arthritis), ankylosing spondylitis (back pain)

42
Q

this MSK disorder parallels gut dz, the others do not

A

peripheral arthritis

43
Q

name 2 ocular disoders seen in IBD; which is worse?

A

uveitis & scleritis; uveitis is worse (both are inflammation)

44
Q

name 4 hepatobiliary disorders associated with IBD

A

PSC, pericholangitis, cholangiocarcinoma, gallstones

45
Q

name 2 additional EIMs seen in IBD

A

mouth ulcers, DVT/PE

46
Q

blood in stool

A

UC

47
Q

mucus

A

UC

48
Q

systemic symptoms

A

CD

49
Q

pain

A

CD

50
Q

abdmominal mass

A

CD

51
Q

perineal/perianal dz

A

CD

52
Q

fistulas

A

CD

53
Q

small intestine/colonic obstruction

A

CD

54
Q

response to ABX

A

CD

55
Q

surgery is effective for (UC/CD)

A

UC

56
Q

cobblestoning

A

CD

57
Q

granulomas

A

CD (40-50%)

58
Q

rectal sparing

A

CD

Gastrointestinal (40 decks)

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