Path-Gastric Neoplasms

Question 1

name two benign gastric neoplasms

Answer 1

leiomyoma and polyps

Question 2

name two malignant gastric neoplasms

Answer 2

adenocarcinoma, lymphoma

Question 3

name two types of gastric adenocarcinoma

Answer 3

intestinal, diffuse

Question 4

the vast majority of malignant gastric neoplasms are?

Answer 4

adenocarcinoma

Question 5

leiomyomas are benign tumors of what tissue? What complications can occur and why?

Answer 5

smooth muscle; ulceration +/- hemorrhage due to stretching and thinning of overlying mucosa

Question 6

hyperplastic polyps are composed of?

Answer 6

regenerating mucosal cells and inflammatory cells

Question 7

infiltrating cancer growth can be particularly severe in the stomach; this is known as ______

Answer 7

linitis plastica

Question 8

ulcerating malignancies can be distinguished from peptic ulcers by?

Answer 8

shaggy edges, heaped margins

Question 9

which LN are enlarged in gastric malignancies?

Answer 9

left supraclavicular (Virchow’s) + periumbilical

Question 10

gastric cancer can invade what locally?

Answer 10

pancreas, duodenum, peritoneal seeding

Question 11

name two pre-existing diseases that contribute to development of gastric adenocarcinoma

Answer 11

h pylori infection; chronic atrophic gastritis (can be autoimmune or from h pylori)

Question 12

diffuse-type gatric adenocarcinoma results in?

Answer 12

poorly differentiation, dis-cohesive mucous cells + desmoplasia (fibrosis) (can lead to linitis plastica)

Question 13

both intestinal and diffuse gastric adenocarcinomas can make?

Answer 13

“lakes” of extracellular mucus

Question 14

both early and advanced gastric adenomas may metastasize, but symptoms and metastasis are more common the ___ of the tumor

Answer 14

deeper the spread (often presents late stage)

Question 15

gastric cancer is said to be advanced when it has infiltrated the?

Answer 15

muscularis propria

Question 16

____ and ____ are more easily spotted on a biopsy of diffuse gastric adenocarcinoma than actual cancer cells

Answer 16

mucin lakes, desmoplasia

Question 17

cancer cells in diffuse gastric adenoCA are called?

Answer 17

signet ring cells

Question 18

which is more significant for prognosis: type of adenocarcinoma or depth of invasion?

Answer 18

depth of invasion

Question 19

how does h pylori lead to lymphoma?

Answer 19

chronic inflammation and influx of B cells become substrate for lymphoma

Question 20

do gastric lymphomas grow slowly or quickly?

Answer 20

slowly (excellent 5 year survival)

Question 21

histopathology of gastric MALToma

Answer 21

small malignant lymphocytes infiltrate mucosa and destroy gastric glands