Path Oral Cavity/Jaw/Glands

Question 1

Aphthous Ulcer Et

Answer 1

• Immune: Celiac, IBS, Behcet
• Idiopathic
• Familial

Question 2

Aphthous ulcer description

Answer 2

single or multiple, shallow, hyperemic ulcerations

Question 3

Pyogenic granuloma

Answer 3

• Female>Male; Pregnancy
• Inflammatory Gingival lesions; Red lobular ulcerating mass
• Tx: Surgical excision

Question 4

What can develop f/ Pyogenic granuloma

Answer 4

Peripheral ossifying fibroma

Question 5

Peripheral ossifying fibroma

Answer 5

• Long-standing PG or de novo f/ peridontal ligament

- Tx: Complete excision down to periosteum

Question 6

Leukoplakia

Answer 6

Premalignant white patch which cannot be scraped off and not characterized as any other Dx

Question 7

Red Velvety, eroded lesions of oral cavity

Answer 7

Erythroplakia -> Carcinoma in situ

Question 8

SCC in India/Asia

Answer 8

• “Betel chewing teeth”

- Betel/Areca nut -> stimulatory, carcinogenic -> SCC

Question 9

Oral SCC Et

Answer 9

• Actinic radiation/sunlight
• Smoking/pipe
• HPV-16
• Betel/Areca nut

Question 10

Molecular mutation in SCC

Answer 10

• p53

- HPV-16 -> p16 cdk

Question 11

Oral SCC Gross smorphology

Answer 11

Raised, firm, pearly plaques on verrucous areas of mucosal thickening

Question 12

Oral SCC distal metastasis

Answer 12

• Mediastinal LNs
• Lungs
• Liver
• Bone

Question 13

HSVI S/S

Answer 13

• Children 2-4

- abrupt onset of vesicles/ulcers, Lymphadenopathy, fever, anorexia

Question 14

HSV1 Histo

Answer 14

• acantholytic epithelium “Tzank” Cells

Question 15

Types of Oral candidias

Answer 15

• Pseudomembranous: Multiple white plawues; easily wiped off to reveal erythematous base
• Erythematous: MEdian rhomboid glossitis, loss of filiform papillae on midline of tongue
• Hyperplastic: White plaques which do not scrape off but responds to clotrimazole

Question 16

White, confluent patches of fluffy, hyperkeratotic thickening on lateral tongue which cannot be scraped off

Answer 16

HAIRY LEUKOPLAKIA

- EBV

Question 17

Sialadenitis Et

Answer 17

• Trauma
• Viral
• Mumps
• Sjogrens
• Neoplastic

Question 18

Sjogrens clinical features

Answer 18

• Parotid enlargement
• Lacrimal inflammation
• Loss of filiform papillae w/ burning sensation

Question 19

Sjogrens PAthology

Answer 19

Activated lymphocyte invasion w/ antibodies against SS-A (Ro) + SS-B (La)

Question 20

Mikulicz syndrome

Answer 20

Combination of Lacrimal + Salivary gland inflammation by any cause

Question 21

Benign Neoplasms of salivary gland

Answer 21

Pleomorphic adenoma
Warthin tumor
Onmcocytoma

Question 22

Malignancies of Salivary gland

Answer 22

Mucoepidermoid carcinoma
Adenocarcinoma
Acinic cell carcinoma
adenoid cystic carcinoma

Question 23

Pleomorphic adenoma morphology

Answer 23

• Mixed tumor (Epithelial, Myxoid, hyaline, chondroid, osseus)
• rounded, well-demarcated < 6 cm

Question 24

Advancement of Pleomorphic adenoma

Answer 24

Carcinoma ex pleomorphic adenoma

Question 25

• Papillary cystadenoma Lymphomatosum
• Only parotid
• Males/Smokers

Answer 25

Warthin Tumor

Question 26

Warthin tumor Morphology

Answer 26

• Round to oval encapsulated masses, 2 to 5 cm in diameter

- narrow cystic or cleft like spaces filled with mucinous or serous secretions

Question 27

onocytic

Answer 27

granular cytoplasm f/ numerous mitochondria

Question 28

Mucoepidermoid carcinoma morphology

Answer 28

Pale and gray-white on transection, they frequently contain small, mucin-containing cysts
~ 8 cm
They lack well-defined capsules and are often infiltrative at the margins….

Question 29

Histologic triad of Mucoepidermoid carcinoma

Answer 29

• epithelial cells
• intermediate cells
• mucocytes