IBD Flashcards
1
Q
Clinical features UC
A
- continuous inflammation
- Colon Only
- superficial
2
Q
Clinical features Crohns Disease
A
- Patchy inflammation
- total GI involvement
- full-thickness inflammation
- formation of fistulas/strictures
3
Q
UC Gross Morphology
A
- Absence of mucosal vascular pattern
- granular mucosa w/ pinpoint hemorrhages
- Mucopus ulcerations
4
Q
UC Histo
A
- N/0 invasion into epithelium of crypts forming Abcesses
- Necrosis + eventual Toxic megacolon
5
Q
UC LabDc
A
- INC ESR + CRP
- Fe-deficient Anemia
- DEC Albumin
- Elevated LFTs
6
Q
Crohns Gross appearance
A
- Apthous or linear ulcers
- Cobblestone mucosa w/ transmural inflammation
7
Q
Crohns LabDx
A
- INC ESR.CRP
- Fe deficiency
- Folate + B12 deficiency
- DEC Total protein
- Non-caseating granuloma on microscope
8
Q
UC/Crohns Tx
A
- Aminosalicylates (5-ANA)
- Abx
- steroids
- Immunomodulators (Anti-TNF)
9
Q
Anti-TNF Agents
A
- Infliximab
- Adalimumab
- Certolizumab
10
Q
Anti-adherence Integrins Agents
A
Natalizumab
Vedolizumab
11
Q
Natalizumab AE
A
Progressive multifocal leukoencephalopathy
