Bacterial Pathogens GI 1 Flashcards
1
Q
Salmonella Path
A
- Taken up by M Cells -> Phagocytosis by DCs -> Multiplication in M0 + spread to other tissues and bloodstream
2
Q
Salmonella S/S + Treatment
A
- Develop 12-72 H after exposure and lasts up to 10 days
- S/S: N/V, cramping/pain, diarrhea (Bloody or nonbloody), fever
- Tx: Abx, supportive
3
Q
Typhoid fever Diagnose
A
- ELISA; Widal NO LONGER used
4
Q
Typhoid PRevention + Tx
A
- Vaccines: Vivotif Live Oral for 5Y protection approved for individuals ove 6 YOr; Typhim injnectable inactivated for 2Y protection
- Tx Abx
5
Q
Salmonella LabDx
A
- Cultures green-blue-green on Hektoen on
6
Q
Shigellosis types
A
- dysenteriae (moist virulent, not in U.S.)
- flexneri (common in U.S.)
- Boydii (rarely in U.S.)
- Sonnei: (least virulent, most common)
7
Q
Dysentray S/S
A
- Fever, cramping, abdominal pain, N/V
- Tenesmus
- HUS Complication f/ Shiga Toxin
- Diarrhea w/ mucus, blood, + WBCs
8
Q
EHEC coinfects w/
A
S/ Sonnei
9
Q
Shigella Path
A
- Invads M Cells and into M0 - cell-to-cell invasion
- Disruption of Cell junction via transmigration of PMNs
10
Q
Shigella Diagnosis
A
- RBCs/WBCs stool sample
- Hektoen agar
- PCR on stool
- O antigen test
11
Q
Shigella Tx
A
- Supportive mostly
- NO antidiarrheals
- Severea cases used Cipro or Azithromycin
12
Q
E. Coli presentation
A
- 1-10 day slow progression of stomach ache -> cramps + bloody diarrhea; N/V
- CComplications: HUS n elderly/IC
13
Q
E. Coli LabDx
A
- ELISA or PCR detec shiga-like toxin in stool
- Lactose fermantation
- Sorbitol MacConkey Agar
- H2S Positive
14
Q
E. Coli Tx
A
- Supportive car
- HUS -> transfusion + dialysis
15
Q
Strains of E. Coli
A
EHEC - Hemorrhagic ETEC - Travelers EIEC - Invasive/Gastroenteritis; No SLT EPEC - Children GastroEnteritis EAEC - Persistent diarrhea in children
