GERD Riskin Flashcards
1
Q
Chief Cell
A
GLP + Pepsinogen
2
Q
D Cells
A
Somatostatin
3
Q
ELCs
A
Histamine
4
Q
Parietal Cell transporters
A
Apical/Lumen: H+/K+ ATPase + Cl- transporter
Basal: Na/K ATPase + XL-/HCO3 antiporter
5
Q
cAMP + Hormones in Parietal Cells
A
Histamine INC cAMP (Gs) -> INC H+/K+ ATPase activity -> INC Acid
Somatostatin + PGEs -> (Gi)DEC cAMP
-> DC Acid
6
Q
IP3/Ca mechanism in parietal cells
A
ACh + CCKb (Gq) -> INC IP3/Ca -> INC H+/K+ ATPase -> INC Acid
7
Q
Misoprostol
A
- PGE1 analogue
- NSAID induced gastric ulcers
8
Q
Contraindication for Antacids
A
Kidney disease (Magnesium)
9
Q
H2 Antagonist Use
A
- 30 min onset
- Last 8 hours
- Can exacerbate immediately before meals
10
Q
guidelines for GERD w/ extraesophageal s/s
A
a trial of a twice-daily proton pump inhibitor be administered for 2–3 months in patients with suspected extraesophageal GERD syndromes who also have typical GERD symptoms
