Parkinson's and Alzheimer's Flashcards
rescue treatment for on-off phenomenon?
Apomorphine (Apokyn)
L-dopa MOA
increase DA levels- replacement therapy
L-dopa interactions (2)
MAO-A inhibitor: HTN crisis
pyridoxine (Vit B6): increased peripheral metabolism of L-dopa, decreased effect
L-dopa contraindications (4)
psychosis
closed angle glaucoma
cardiac disease
malignant melanoma
MAOIs that inhibit MAO-B in CNS (2)
Selegiline (Deprenyl)
Rasagiline (Azilect)
MAOI SE (3)
insomnia: amphetamine-like metabolites
severe HTN if combined with phenelzine or other MAOIs
will increase SE of L-dopa later in disease
MAOI drug interactions (3)
meperidine: stupor, rigidity, agitation, possible serotonin syndrome
TCAs or SSRIs: Serotonin syndrome
Talcapone (Tasmar) MOA
inhibit DA & L-dopa metabolism in CNS & periphery –> increases pool of L-dopa for transport into the brain
Entacapone (Comtan) MOA
inhibits DA & L-dopa metabolism in the periphery only –> increases the pool of L-dopa for transport into the brain
which COMT inhibitor is associated w/ death from hepatic failure
Tolcapone (Tasmar)
which COMT inhibitor is assoc. w/ orange pee?
Entacapone (Comtan)
transdermal patch for PD and restless leg syndrome
Rotigotine (Neupro)
DA receptor agonist unique use in Parkinson’s
continue to be effective as disease progresses due to direct action
Bromocriptine (Parlodel) drug type & SE (2)
ergot derivative
vasospasms
erythromelalgia
DOC for restless leg syndrome
Ropinirole (Requip)
