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Pharm 3 > Immunopharmacology > Flashcards

Immunopharmacology Flashcards

1
Q

cyclosporine SE (3)

A

renal toxicity
HTN**
gingival hyperplasia**

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2
Q

tacrolimus cautions/SE (3)

A

nephrotoxic
HTN
hyperglycemia

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3
Q

tacrolimus uses, dosing (3)

A

prevent rejection in transplantation- esp. liver, kidney, and heart

IV, oral, topical

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4
Q

sirolimus SE (2)

A

no renal toxicity

elevated TGs & cholesterol

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5
Q

Pimecrolimus use

A

atopic dermatitis

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6
Q

Mycophenolate use (2) & SE (3)

A

prevent rejection post-transplant
specific to immune cells

rash, GI, infections

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7
Q

thalidomide use, SE (3)

A

prevents graft-vs-host rxn

teratogenic
drowsiness
neutropenia

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8
Q

Azathioprine use (3)

A

prevents rejection
tx GN in lupus, severe RA

decr. dose if using w/ allopurinol

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9
Q

Azathioprine SE (2)

A

BM suppression

liver toxicity

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10
Q

Cyclophosphamide MOA (2)

A

blocks response to new antigens

can inhibit established immune response

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11
Q

Cyclophosphamide use (3)

A

organ transplant rescue
BM transplant
severe autoimmune disease

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12
Q

Cyclophosphamide SE (2)

A 
hemorrhagic cystitis (hydration, MESNA)
bladder fibrosis
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13
Q

MTX use (5)

A 
organ transplants
RA
psoriasis
antineoplastic
severe asthma
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14
Q

MTX SE (2)

A

alopecia

hepatotoxicity

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15
Q

muromanab CD3 use

A

allergic rxn- give with corticosteroids to decr. rxn

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16
Q

daclizumab/basiliximab use

A

kidney transplants, right after transplant

17
Q

Bevacizumab, ranibizumab MOA, use, SE (3)

A

bind VEGF-A
macular degeneration

thromboembolism, stroke, MI

18
Q

IL-2 uses (2), SE (3)

A

renal cell carcinoma
malignant melanoma

pulm. edema, severe hypotension, hematological

19
Q

Filgastrin (Neupogen) use and SE (2)

A

neutropenia

bone pain, injection site rxn

20
Q

Epoetin-alfa SE (2)

A

HTN

incr. risk thrombosis/stroke

21
Q

interferon alfa-2b use? (2)

A

hep C

severe uveitis

Pharm 3 (15 decks)

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