Immunopharmacology Flashcards
cyclosporine SE (3)
renal toxicity
HTN**
gingival hyperplasia**
tacrolimus cautions/SE (3)
nephrotoxic
HTN
hyperglycemia
tacrolimus uses, dosing (3)
prevent rejection in transplantation- esp. liver, kidney, and heart
IV, oral, topical
sirolimus SE (2)
no renal toxicity
elevated TGs & cholesterol
Pimecrolimus use
atopic dermatitis
Mycophenolate use (2) & SE (3)
prevent rejection post-transplant
specific to immune cells
rash, GI, infections
thalidomide use, SE (3)
prevents graft-vs-host rxn
teratogenic
drowsiness
neutropenia
Azathioprine use (3)
prevents rejection
tx GN in lupus, severe RA
decr. dose if using w/ allopurinol
Azathioprine SE (2)
BM suppression
liver toxicity
Cyclophosphamide MOA (2)
blocks response to new antigens
can inhibit established immune response
Cyclophosphamide use (3)
organ transplant rescue
BM transplant
severe autoimmune disease
Cyclophosphamide SE (2)
hemorrhagic cystitis (hydration, MESNA) bladder fibrosis
MTX use (5)
organ transplants RA psoriasis antineoplastic severe asthma
MTX SE (2)
alopecia
hepatotoxicity
muromanab CD3 use
allergic rxn- give with corticosteroids to decr. rxn
daclizumab/basiliximab use
kidney transplants, right after transplant
Bevacizumab, ranibizumab MOA, use, SE (3)
bind VEGF-A
macular degeneration
thromboembolism, stroke, MI
IL-2 uses (2), SE (3)
renal cell carcinoma
malignant melanoma
pulm. edema, severe hypotension, hematological
Filgastrin (Neupogen) use and SE (2)
neutropenia
bone pain, injection site rxn
Epoetin-alfa SE (2)
HTN
incr. risk thrombosis/stroke
interferon alfa-2b use? (2)
hep C
severe uveitis
