Gout Drugs

Question 1

colchicine effects & usage (3)

Answer 1

decreased inflammation & pain in acute attacks
effective in 12-24 h
oral

Question 2

colchicine SE (3)

Answer 2

severe diarrhea
N/V
abd pain

Question 3

NSAIDs used for gout (4) and not used (2)

Answer 3

indomethacin, naproxen, sulindac, celecoxib

aspirin & salicylates

Question 4

uricosuric agents (4)

Answer 4

probenecid
allopurinol
febuxostat
rasburicase

Question 5

uricosuric agents SE (3)

Answer 5

risk of kidney stones
may trigger acute gouty attack initially
GI irritation

Question 6

probenecid tx guidelines (2)

Answer 6

oral

don’t start within 2-3 weeks after an acute attack

Question 7

allopurinol & febuxostat MOA and tx use

Answer 7

inhibits xanthine oxidase –> inhibits uric acid synthesis

tx primary & secondary gout

Question 8

allopurinol & febuxostat SE (4)

Answer 8

vasculitis
agranulocytosis
hypersensitivity
may provoke attack initially

Question 9

allopurinol drug interactions (3)

Answer 9

warfarin
probenecid
fluorouracil

Question 10

rasburicase (Fasturtec) MOA

Answer 10

catalyzes oxidation of uric acid to allantoin, which is excreted

Question 11

rasburicase (Fasturtec) SE

Answer 11

risk for tumor lysis syndr. in pts w/ hematological malignancies
—> hyperuricemia

Question 12

colchicine MOA

Answer 12

binds to tubulin –> inhibits leukocyte migration & phagocytosis –> decr. inflammation & pain