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Pharm 3 > Antipsychotics & Mood Stabilizers > Flashcards

Antipsychotics & Mood Stabilizers Flashcards

0
Q

atypical antipsychotics MOA (3)

A

block 5-HT & DA receptors
mesocortical system
both positive & negative sx

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1
Q

classical antipsychotics MOA (3)

A

block DA D2 receptors
target mesolimbic system
alleviate the positive sx

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2
Q

extrapyramidal symptoms occur due to?

A

blockage of DA receptors in the nigrostriatal pathway
imbalance of striatal DA & ACh

degree of EPS is based on anticholinergic activity of the drug

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3
Q

tx EPS?

A

Benztropine to restore ACh/DA

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4
Q

chlorpromazine (Thorazine) use, MOA?

A

psychosis associated w/ mania & drugs of abuse, anti-emetic, pre-anesthetic

blocks DA D2 receptors; also has a-adrenergic

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5
Q

chlorpromazine unique SE?

A

browning of vision due to retinal deposits

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6
Q

degree of EPS is determined by?

A

anticholinergic activity of the drug

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7
Q

least likely drugs to cause tardive dyskinesia? (2)

A

clozapine

olanzapine

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8
Q

haloperidol SE

A

EPS

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9
Q

clozapine (Clozaril) unique SE (2)

A

hypersalivation

agranulocytosis

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10
Q

olanzapine (Zyprexa) MOA and unique use

A

blocks 5HT-2a, D4, and D2

also used for bipolar

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11
Q

olanzapine (Zyprexa) SE (4)

A 
sedation
orthostatic hypotension
wt gain
hyperglycemia
(wt. gain and hyperglycemia = Olanzapine, Obese)
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12
Q

first line drug for psychosis?

A

Risperidone (Risperdal)

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13
Q

Risperidone MOA and unique SE

A

blocks 5-HT & DA D2

increased QT interval

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14
Q

Ziprasidone (Geodon) MOA (3) and unique uses (2)

A

blocks DA D2 and 5-HT receptors
5-HT1a agonist
some antidepressant activity
Tourette’s, acute mania

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15
Q

Ziprasidone (Geodon) SE (4)

A

increased QT interval
sedation, impairs cognition
increased prolactin
caution in hx seizures

16
Q

Quetiapine (Seroquel) MOA & use

A

blocks 5-HT2a & DA D2

promotes sleep onset & maintenance

17
Q

Quetiapine (Seroquel) contraindication

A

elevated prolactin

18
Q

Aripraprazole (Abilify) MOA (3)

A

partial agonist DA D2 & 5-HT
antagonist for 5-HT2a

dopamine system stabilizer: low DA tone –> receptors activated, opposite for high DA tone

19
Q

Aripiprazole (Abilify) unique SE

A

decreased esophageal motility

20
Q

DOC bipolar?

A

Lithium

21
Q

Lithium drug interactions (3)

A

antidepressants: may increase mania
diuretics: alter Li+ clearance
NSAIDs: increase Li+ toxicity, decrease clearance, increase uptake

22
Q

Lamotrigine (Lamictal) use (3)

A

prevention of relapse in bipolar
depressive state following mania
acute mania

Pharm 3 (15 decks)

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