GI drugs

Question 1

antacids incr. elimination of (2)

Answer 1

phenobarbital

salicylates

Question 2

H2 antagonists (4)

Answer 2

Cimetidine (Tagamet)
Ranitidine (Zantac)
Famotidine (Pepcid)
Nizatidine (Axid)

Question 3

H2 antagonist use (4)

Answer 3

ulcers
GERD
pre-anesthesia
w/ H1 antagonists for severe allergic rxn

Question 4

Cimetidine SE

Answer 4

anti-testosterone effects

Question 5

H2 antagonist SE (4)

Answer 5

confusion in the elderly
HA
dizziness
rash/itch

Question 6

PPI MOA (3)

Answer 6

-prazole

activated in gastric parietal cell
inactivates H+ pumps
irreversible block of acid formation

Question 7

PPI uses (4)

Answer 7

DOC GERD
ulcers
pts on NSAIDs
Zollinger-Ellison Syndr.

Question 8

PPI SE (2)

Answer 8

osteoporosis

omeprazole- possible interactions w/ phenytoin, warfarin, diazepam, clopidigrel

Question 9

Sucralate (Carafate) MOA, SE (2), & interactions

Answer 9

polymerizes to form protective barrier
constipation
stomach upset- take on an empty stomach
drug interactions w/ Aluminum

Question 10

misoprostol (Cytotec) MOA, use, SE, contraindication

Answer 10

PG E1 analogue
prevent or decrease NSAID-induced damage
diarrhea, nausea
contraindicated in pregnancy- can induce abortion

Question 11

Metoclopramide MOA, use

Answer 11

D2 agonist, incr. ACh release

antiemetic, used to incr. GI motility in hospitalized pts

Question 12

Metoclopramide SE & contraindication

Answer 12

Parkinson’s-like sx

pregnancy- methemoglobinemia

Question 13

Erythromycin use

Answer 13

diabetic gastroparesis

Question 14

DOC IBS

Answer 14

Amitryptiline

Question 15

Alosetron (Lotrenox) MOA, use

Answer 15

5HT3 receptor antagonist

IBS w/ severe diarrhea in women

Question 16

Alosetron (Lotrenox) SE, contraindications

Answer 16

constipation, GI obstruction, perforation

risk-benefit statement required due to many contraindications

Question 17

-setron MOA, use

Answer 17

5HT3 antagonists

N/V due to chemo, gastric diseases (Not motion sickness)

Question 18

Prochlorperazine, Promethazine MOA, use, SE

Answer 18

block DA, muscarinic, histamine receptors

chemo, post-op, gastroenteritis, motion sickness

highly sedating

Question 19

methylcellulose, psyllium, polycarbophil

drug type & use instruction

Answer 19

bulk-forming laxatives

take w/ plenty of water

Question 20

osmotic laxatives (3)

Answer 20

magnesium hydroxide
Na+ salts
sorbitol, mannitol, sucralose

Question 21

Polyethylene glycol use (2)

Answer 21

prep for colonoscopy

Miralax for occasional constipation

Question 22

Lactulose use

Answer 22

cirrhosis & liver disease to decr. blood ammonia levels

Question 23

bisacodyl, senna

Answer 23

mucosal agents

Question 24

mineral oil SE (3)

Answer 24

lose fat-soluble vitamins
aspiration pneumonia
leaky butt

Question 25

best lubricant/softener

Answer 25

docusate

Question 26

Lubiprostone (Amitiza) MOA (2), effects (2)

Answer 26

PG E1 analogue
activates Cl- channels in luminal cells to incr. fluid secretion

no effect on electrolytes
no laxative dependence

Question 27

bismuth salicylate use, effects

Answer 27

traveller’s diarrhea

absorbs water, pathogens
anti-inflammatory

Question 28

antacids decrease absorption of (3)

Answer 28

digoxin
phenytoin
propranolol