parkinson

Question 1

Parkinsons goal of therapy

Answer 1

improve ability to perform ADLs

Question 2

Parkinsons dopaminergic agent

Answer 2

levodopa =dopamine receptor activation

Question 3

Parkinsons anticholinergic agent

Answer 3

benztropine= prevent cholinergic receptor activation

Question 4

Parkinsons initial tx

Answer 4

MOABi-selegiline or rasagiline

Question 5

Parkinsons severe sx tx

Answer 5

levodopa w carbidopa or a dopamine agonist

Question 6

Parkinsons mgmt of motor fluctuation

Answer 6

dopamine agonist, COMTi, MAOBi

Question 7

levodopa only given in combo w

benefits diminish over time

Answer 7

carbidopa=vN/V or carbidopa/entacapone=^levodopas half life

d/t dyskinesias

Question 8

Levodopa -reduce ___intake

Can ^____ behavior

Answer 8

protein

impulsive

Question 9

levodopa dyskinesia mgmt

Answer 9

lower dose

give amantadine

Question 10

Levodopa AE

Answer 10

darkens sweat/urine

activates malignant melanoma =do skin checks

Question 11

Nonergot dopamine agonist

Answer 11

pramipexole,ropinirol- used in early PD, ^Impulsive
rotigitine-early tx, ^sweat
Apomorphine- hypomobility tx (NOT routine)

Question 12

Ergot Derivatives

Answer 12

Bromocriptine=can use vDose of levodopa

babergoline

Question 13

COMTi

Answer 13

entacapone=vLevodopa metabolism(^impulsive)

Tolcapone-BBW liver failure