asthma/copd meds

Question 1

2 Leukotriene modifiers w SE of reversible hepatitis, CYP450 interaction w warfarin, propranolol, theophyline

Answer 1

Zileuton

Zafirleukast

Question 2

cromolyn

Answer 2

Antiinflammatory

Mast cell stabilizer

Question 3

for severe eosinophilic asthma
for add on therapy
treat for helminths first

Answer 3

Monoclonal antibody

IL-5 inhibitor (-mab)

Question 4

Phosphodiesterase-4 inhibitor

COPD exacerbation prophylaxis
not for pregnant/lactating)

Answer 4

Roflumilast

Question 5

Asthma and COPD
long term control
Must always use w ICS for asthma

Answer 5

LABAs

Question 6

LABAs AE

Answer 6

angina, tremor, ^HR

Question 7

Maintenance for asthma only

Narrow therapeutic index

Answer 7

(Methylxanthines)
theophylline
Narrow therepeutic index 30+=v-fib/convulsion, cardioresp collapse

Question 8

Anticholinergic
Ipratropium
(vBronchoconstriction)

Answer 8

relief w/in 30 sec

AE: dry mouth, pharnyx irritation, glaucoma, CV events

Question 9

2 long acting Anticholinergics for COPD maintenance only

Answer 9

Tiotropium

Aclidinium

Question 10

Anticholinergic inhaled drug for COPD mgmt

AE: hypersensitivity w milk allergy

Answer 10

Umeclidinum

Question 11

Long term Maintenace

-sone/-terol

Answer 11

Glucocorticoid/Laba

Question 12

Leukotriene modifiers AE requiring monitoring for teens

Answer 12

Neuropsych: SI, depression

Question 13

Long acting anticholinergic nebulized daily for COPD

Answer 13

Revefenacin