Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

D&T 4 exam 1 > Parathyroid - Denning > Flashcards

Parathyroid - Denning Flashcards

1
Q

what is the parathyroid derived from

A

descending pharyngeal pouches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

PTH activates what process in bones

A

osteoclasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

PTH activates what process in kidney

A

reabsorption of Ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the net effect of primary hyper-PTH

A

bone resorption
renal disease
- incrase ionized Ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the most common sign for primary hyper-PTH

A

increased ionized Ca

“ painful bones, renal stones, abdominal groans and psychic moans”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

where does primary hyper-PTH mets

A

bones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is cellularly wrong with primary hyper-PTH

A

inversion of chromosome 11

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is genetically wrong with MEN I

A

Chromosome 11q13

- putative suppressor gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what does adenoma look like with primary hyper-PTH

A

RIM of compressed normal parathyroid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what does hyperplasia look like with primary hyper-PTH

A

diffuse enlargement of 2 or more glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what usually causes hyperplasia primary hyper-PTH

A

sporadic

MEN I or IIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how is primary hyper-PTH treated

A

surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the number one cause of secondary hyperparathyroidism

A

renal failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

signs and symptoms of secondary hyperparathyroidism

A

bone abnormalities

Calciphylaxis: due to increased phosphates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

when does tertiary hyperparathyroidism occur

A
  • secondary to hyper-PTH becomes autonomous and excessive
  • hyperplasia
  • hypercalcemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the primary (idiopathic) cause of hypoparathyroidism

A

auto-ab’s directed against Ca-sensing receptor

17
Q

what is a genetic cause of hypoparathyroidism? what is onset presentation

A

Familial hypoparathyroidism

Candidiasis

18
Q

signs and symptoms of hypoparathyroidism

A

Tetany
Chvostek sign
Trousseau sign

19
Q

Chvostek sign

A

tap along facial nerve, induce contractions of muscle of eye, mouth or nose

20
Q

Troussaeu sign

A

inflate BP cuff, induce carpal spasm, goes away when deflate the cufff

21
Q

what is the common theme of pseudohypo-PTH disorders

A

end-organ resistance to normal or elevated PTH

22
Q

what are defects of pseudohypo-PTH disorders

A

Pseudohypoparthyroidism Type 1

Pseudohypoparthyroidism Type 2

23
Q

Pseudohypoparthyroidism Type 1

A
  • dinimished cAMP response to PTH
24
Q

clinical features of Pseudohypoparthyroidism Type 1

A

round faces,
short starure
short metacarpal and metatarsal bones
Albright Hereditary osteodystrophy

25
Q

Pseudohypoparthyroidism Type 2

A

normal PTH-induced cAMP

26
Q

Pseudohypo-PTH causes what

A

secondary parathyroid hyperfunction due to the hypocalcemia

D&T 4 exam 1 (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions