Drug therapy in pregnancy

Question 1

Diethylstilbestrol was used for

Answer 1

prevention of premature birth, miscarriage and pregnancy problems

Question 2

Diethylstilbestrol is bad because

Answer 2

clear cell adenocarcinoma of vaginia

Question 3

what is Bendectin used for

Answer 3

nausea/vomiting during pregnancy

- withdrawn with no evidence

Question 4

Thalidomide ? why was it withdrawen ? what is used for today

Answer 4

• control nausea/vomiting
• altered face/ear
• chemotherapy

Question 5

what drugs do not pass to fetus

Answer 5

insulin and heparin

Question 6

A

Answer 6

• studies failed to demonstrate a risk to the fetus in the first trimester of pregnancy
• (and there is no evidence of risk in later trimesters).

Question 7

B

Answer 7

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women

Question 8

C

Answer 8

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Question 9

D

Answer 9

There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Question 10

X

Answer 10

Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Question 11

treat bacterial vaginosis

Answer 11

metroidazole

Question 12

treat vaginal candidiasis

Answer 12

topical azoles

Question 13

treat UTI

Answer 13

penicillins

Question 14

side effects of iron of folic acid

Answer 14

nausea and constipation

Question 15

treat hyperthyroidism

Answer 15

carbimazole

propylthiouricil

Question 16

diabetic drug

Answer 16

mefromin 2/3 trimester

Question 17

treatment of pre-eclamptic

Answer 17

delivery

hydralazine, methyldopa, labetalol

Question 18

pre-eclamptic what do you not used

Answer 18

Ace
Arb
nitroprusside

Question 19

Phenytion

Answer 19

fetal hydantion sydnrome

Question 20

carbamazepine

Answer 20

neural tube defect

Question 21

valporic acid

Answer 21

neural tube dificits

Question 22

asthma treatment

Answer 22

inhaled glucocorticouds first line
systemic
leukotrience inhibits -3

Question 23

higher doses of Ondansetron

Answer 23

QT prolongation

Question 24

hyperemesis gravidarium

Answer 24

severe nausea/vomiting

Question 25

treatment of depression

Answer 25

Sertaline- safest

Paxil- cardiac defects

Question 26

problem with tobacco abuse

Answer 26

premature labor, low birth weigh