Drug therapy in pregnancy Flashcards
Diethylstilbestrol was used for
prevention of premature birth, miscarriage and pregnancy problems
Diethylstilbestrol is bad because
clear cell adenocarcinoma of vaginia
what is Bendectin used for
nausea/vomiting during pregnancy
- withdrawn with no evidence
Thalidomide ? why was it withdrawen ? what is used for today
- control nausea/vomiting
- altered face/ear
- chemotherapy
what drugs do not pass to fetus
insulin and heparin
A
- studies failed to demonstrate a risk to the fetus in the first trimester of pregnancy
- (and there is no evidence of risk in later trimesters).
B
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women
C
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
D
There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
X
Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
treat bacterial vaginosis
metroidazole
treat vaginal candidiasis
topical azoles
treat UTI
penicillins
side effects of iron of folic acid
nausea and constipation
treat hyperthyroidism
carbimazole
propylthiouricil
