Ovarian disease Flashcards
where do cystic follicle originate
unruptured graafian follicles or
follicles that ruptured and then sealed
What is luteal cyst lined with and what does it secrete? what happens when ruptured
luteinized granulosa cells
progesterone
peritoneal reaction
Stein-Levanthall syndrome
polycystic ovaries
Stein-Levanthall syndrome impact on insulin
insulin resistance
classification of ovarian tumors
surface epithelium
germ cells
sex cord - stroma
what is thought to give rise to epithelial neoplasia
cortical inclusions cysts
when do benign/boderline and malignant serous tumor occur
benign/boderline: younger
malignant: older
serous tumor gros presentation? bilateral or unilateral?
smooth-walled cyst
cyst with papillary excrescences
bilateral
histo for serous tumor
ciliated columnar cells
intercalted cell
is there invasion of boderline serous tumor
no
gross for malignant serous cystadenocarcinoma
more solid
invasion of ovarian stroma
histo for malignant serous cystadenoma
psammoma bodies
who gets mucinous tumors
middle age
which in more common mucinous or serous
serous
histo for mucinous benign
tall columnar cells with apical mucin
no cilia
what does benign mucinous resemble
cervix or intestines
gross for benign mucinous
multiloculated with tenacious mucous
histo for boderline mucinous tumor
complex glandular structures with nuclear atypia
what does malignant mucinous cystadenoma resemble? benign
malignant: intestinal epithelium
benign: cervical epithelium
what is pseudomyxomatous peritonei
extensive mucinous ascites
epithelial implants and adhesions
what other organ should be considered for pseudomyxomatous peritonei
appendix
what is an aggressive variant endometrioid adenocarcinoma
clear cell adenocarcinoma
what is cystadenofibroma? what is epithelium
benign fibrous stroma
- endometrioid, serous, mucinous or transitional
What is brenner Tumor
Epithelial component is transitional (bladder)
benign
epithelial tumors extend beyond ovary what can happen
peritoneal seeding with massive ascites filled with malignant cells
tumor marker for epithelial cells? prognosis?
CA-125
poor prognosis
how can you help with epithelial prevention
fallopian tube ligation
oral contraceptive therapy
BRCA mutations
germ cell tumors are equivalent to what in males
testicular germ cells
another name for germ cell tumor, benign teratomas
dermoid cyst
who gets germ cell tumor, benign teratomas
young women
germ cell tumor, benign teratomas is dervied from what
ectodermal
3 germ layers
chromosome for germ cell tumor, benign teratomas
46 XX
Immature/malignant teratomas tissue resembles what
same found in fetus or embryo
how is treated
chemotherapy
Immature/malignant teratomas gross apperace
smooth capsule
predominantly solid
necrosis/hemorrhage
Monodermal teratomas
struma ovarii ( thyroid)
Dysgerminoma? who gets it
childhood and young adults
gonadal dysgenesis
Dysgerminoma secretes what hormone
hCG
dysgerminoma histo
large vesicular cells with clear cytoplasm
well-defined cell borders
fibrous stroma containing lymphocytes
Dysgerminoma treatement
radiotherapy
what is endodermal sinus tumor
extraembryonic yolk sac structure
what are markers in endodermal sinus tumor
alpha-fetoprotein
alpha-1-antitrypsin
endodermal sinus tumor prognosis and treatement
bad
chemotherapy
sex cord: granulosa-theca tumor what does it secrete
secretes estrogen and inhibin
sex cord: granulosa-theca tumor gross
yellow due to lipid
sex cord: granulosa-theca tumor histo
granulosal: call-exner bodies, sheets, strands
thecal: clusters or sheets of cuboidal to polygonal cells
sex cord: fibroma-thecoma
fibroblast or plump spindle cells with lipid droplets
sex cord: fibroma-thecoma hist
increased nuclear/cytoplasmic ratio
FIBROSARCOMAS
sex cord: fibroma-thecoma associated with what syndrome
basal cell nevus
what is Meigs syndrome
pelvic pain
mass
ascites
hydrothorax
fibroma-thecoma
most common tumor metastatic tumor to ovary
Kruckenberg tumor
