Parasitology Flashcards
What are the sx of giardiasis
Bloating, flatulence, foul-smelling diarrhea
This protozoa is often seen in campers/hikers and results in bloating, flatulence, foul-smelling diarrhea
Giardia lamblia
Giardia lamblia is transmitted how? And can be dx by?
Cysts in water, trophozoites or cysts in stool
The treatment for giardiasis is
Metronidazole
This protozoa causes vaginitis that is characterized by foul-smell, greenish discharge, itching and burning
Trichomonas vaginalis
How is trichomonas vaginalis transmitted?
Sexually
Trichomonas vaginalis is dx how?
Trophozoites (motile) on wet mound
The treatment for trichomonas vaginitis is
Metronidazole
Chagas disease is cased by what organism
Trypanosoma cruzi
What are the three sx characteristic of Chagas, and what part of the world do you find this disease
dilated cardiomyopathy, megacolon, megaesophagus; South America
What is the treatment for Chagas disease
Nifurtimox
The reduviid bug (kissing bug”) is responsible for the transmission of this organism”
Trypanosoma cruzi
Trypanosoma cruzi infection can be dx by
Blood smear
African sleeping sickness can be caused by what two organisms?
Trypanosoma gambiense, Trypanosoma rhodesiense
What are the sx of African sleeping sickness?
Enlarged lymph nodes, recurring fever (due to antigenic variation), somnolence, coma
The tsetse fly is responsible for transmission of what organism?
Trypanosoma gambiense and Trypanosoma rhodesiense
The treatment for blood borne African sleeping sickness is..?
Suramin
SURe is nice to go to sleep.
The treatment for African sleeping sickness that has penetrated the CNS is
Melarsoprol - MELAtonin helps with sleep
Trypanosoma gambiense and Trpanosoma rhodesiense can be diagnosed by
Blood smear
Leishmania donovani cause what disease
Visceral leishmaniasis (kala-azar)
What are the sx of visceral leishmaniasis
spiking fevers, hepatosplenomegaly, pancytopenia
The sandfly transmits what organism?
Leishmania donovani
Leishmania donovani is transmitted by what organism?
Sandfly
How do you diagnose infection by Leishmania donovani?
Macrophages containing amastigotes
What is the treatment for visceral leishmaniasis
Sodium stibogluconate
Name the four types of malaria
Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, Plasmodium falciparum
What are the common sx of malaria
Cyclic fever, headache, anemia, splenomegaly
What types of Plasmodium have dormant forms in liver (hypnozoites) and causes relapsing malaria?
P. vivax and P. ovale
What Plasmodium cases severe malaria that can affect CNS
P. falciparum
What is the treatment for malaria?
Chloroquine (primaquine to prevent relapse caused by P. vivax, P. ovale), sulfadoxine + pyrimethamine, mefloquine, quinine
What are the symptoms of Babesiosis
fever and hemolytic anemia
How is Babesia transmitted?
Ixodes tick
What is a protozoa that is transmitted by the Ixodes tick
Babesia
What is a Maltese cross
A classic sign of Babesiosis: a RBC has no RBC pigment and a cross shape can be seen
What RBC forms are seen in babesiosis
Maltese cross and ring forms
What are the treatments for babesiosis
Quinine, clindamycin
Cryptosporidium causes what condition
Mild disease (watery diarrhea) in non-immunocompromised. Severe diarrhea in AIDS.
How is Cryptosporidium transmitted? diagnosed?
Cysts in water, cysts on acid-fast stain
There is no treatment for Cryptosporidium: true or false
TRUE
What protozoa causes brain abscess in HIV and birth defects?
Toxoplasma gondii
How is Toxoplasma gondii transmitted?
Cysts in meat or cat feces; crosses placenta (pregnant women should avoid cats)
Why should pregnant women avoid cats?
Risk of Toxoplasma gondii transmission.
How is Toxoplasma gondii infection diagnosed?
Serology, biopsy
How is Toxoplasma gondii infection treated?
Sulfadiazine and pyrimethamine
What organism can cause bloody diarrhea, liver abscess, and RUQ pain?
Entamoeba histolytica; Amebiasis
How is Amebiasis transmitted
Cysts in water
How is amebiasis dx?
Serology and/or trophozoites or cysts in stool; RBCs in cytoplasm of entmoeba
Treatment for Entamoeba histolytica infection
Metronidazole and iodoquinol
Naegleria fowleri is responsible for what disease
Rapidly fatal meningoencephalitis
Rapidly fatal meningoencephalitis is caused by what protozoa?
Naegleria fowleri
How is Naegleria fowleri transmitted?
Swimming in freshwater lakes (enter via cribriform plates)
How is Naegleria fowleri diagnosed?
Amoebas in spinal fluid
What organism causes anal pruritus and can be detected using the Scotch tape test? Is it a nematode or a cestode?
Enterobius vermicularis; nematode
How is Enterobius vermicularis transmitted?
Food contaminated with eggs leading to intestinal infection, causes anal pruritus
What is the treatment for Enterobius vermicularis
Mebendazole (MBZ) and pyrantel pamoate
What organism is the giant roundworm?
Ascaris lumbricoides
What organism is also known as a pinworm?
Enterobius vermicularis
What is the treatment for infection by Ascaris lumbricoides?
Mebendazole (MBZ) and pyrantel pamoate
How is Trichinella spiralis transmitted?
Undercooked meat, usually pork
What disease does Trichinella spiralis cause?
Inflammation of muscle (larvae encyst in muscle), periorbital edema
What is the treatment for Trichinella spiralis
Thiabendazole
What type of helminth is Trichinella spiralis?
Nematode
What type of helminth is Strongyloides stercoralis?
Nematode
What helminth has larvae in soil that penetrates the skin, leading to intestinal infection that causes vomiting, diarrhea, and anemia?
Strongyloides stercoralis
What is the treatment for infection by Strongyloides stercoralis
Ivermectin/thiabendazole
What two organisms are known as hookworms?
Ancyclostoma duodenale, Necator americanus
How do hookworms transmit and what disease do they cause?
Larvae penetrate skin of feet; intestinal infection can cause anemia (sucks bblood from intestinal wall)
What is the treatment for Ancyclostoma duodenale infection?
Mebendazole/pyrantel pamoate
What is the treatment for Necator americanus infection?
Mebendazole/pyrantel pamoate
How is Dracunculus medinensis transmitted?
In drinking water
What type of disease does Dracunculus medinensis cause?
Skin inflammation and ulceration
What is the treatment for Dracunculus medinensis infection?
Niridazole
What organism is transmitted by female blackflies?
Onchocerca volvulus
What organism causes river blindness with skin nodules and lizard skin”?”
Onchocerca volvulus
What disease does Onchocerca volvulus cause?
River blindness with skin nodules and lizard skin””
What is the treatment for Onchocerca volvulus infection?
Ivermectin
What type of helminth is Onchocerca volvulus?
Nematode
What helminth can cause an allergic reaction to its microfilaria?
Onchocerca volvulus
What are the vectors for loa loa?
Deer fly, horse fly, and mango fly
What occurs with loa loa infection?
Swelling in skin and worm can be seen crawling in the conjunctiva
What is the treatment for Loa loa infection?
Diethylcarbamazine
What helminth is carried by the female mosquito and causes elephantitis?
Wuchereria bancrofti
What type of helminth is Loa loa
Nematode
What type of helminth is Wuchereria bancrofti
Nematode
How long after the initial bite does it take to get elephantitis symptoms
9 months to year after bite from Wucheria bnacrofti
What is the treatment for wucheria bancrofti infection?
Diethylcarbamazine
How is Toxocara canis transmitted?
Food contaminated with eggs.
What organism causes granulomas (if they are in retina –> blindness) and visceral larva migrans
Toxocara canis
What is the treatment for Toxocara canis infection?
Diethylcarbamazine
How is Taenia solium transmitted?
Ingestion of larvae encysted in undercooked pork leading to intestinal tapeworms.
What kind of helminth is Taenia solium
Cestode
Ingestion of Taenia solium eggs leads to what?
Cysticercosis and neurocysticercosis
What is the treatment for Taenia solium intestinal worms and cysticercosis?
Praziquantel
What is the treatment for Taenia solium neurocysticercosis?
Albendazole
How is Diphyllobothrium latum transmitted?
Ingestion of larvae in raw freshwater fish
What cestode causes vitamin B12 deficiency, resulting in anemia
Diphyllobothrium latum (fish tapeworm)
How is Echinococcus granulosus transmitted?
Ingestion of eggs in dog feces
What organism can cause cysts in liver and cause anaphylaxis if antigens of the organism are released from the cysts?
Echinococcus
What is the treatment for Echinococcus granulosus?
Albendazole
What type of helminth is Echinococcus granulosus?
Cestode
What kind of disease can Echinococcus granulosus cause?
Cysts in liver; Anaphylaxis if echinococcal antigens are released from cysts
What type of helminth is Diphyllobothrium latum
Cestode
What are the hosts for Schistosoma
Snails
What stage of Schistosoma penetrate skin of humans?
Cercariae
Chronic infection with this organism can lead to squamous cell carcinoma of the bladder.
Schistosoma haematobium
What helminth has cercariae penetrate skin of humans and then goes on to cause granulomas, fibrosis, and inflammation of the spleen and liver?
Schistosoma
What is the treatment for Schistosoma infection?
Praziquantel
What kind of helminth is Schistosoma?
Trematode (fluke)
How is Clonorchis sinensis transmitted?
By uncooked fish
What disease does clonorchis sinensis cause?
Inflammation of the biliary tract leading to pigmented gallstones. It is also associated with cholangiocarcinoma
What is the treatment for clonorchis sinensis infection?
Praziquantel
What organism is transmitted by uncooked fish and causes inflammation of the biliary tract?
Clonorchis sinensis
What organism is transmitted through undercooked crab meat?
Paragonimus westermani
What helminth causes inflammation and secondary bacterial infection of the lung and is transmitted through undercooked crab meat?
Paragonimus westermani
What is the treatment for Paragonimus westermani infection?
Praziquantel
What kind of disease does Paragonimus westermani infection cause?
Inflammation and secondary infection of the lung
What three nematodes are ingested?
(EAT) Enterobius, Ascaris, Trichinella
What three nematodes are infect cutaneously?
(SANd) Strongyloides, Ancylostoma, Necator
What parasite causes brain cysts, and seizures?
Taenia solium (cysticercosis)
What parasite cauess liver cysts?
Echinococcus granulosus
What parasite causes B12 deficiency?
Diphyllobothrium latum
What parasite causes biliary tract disease?
Clonorchis sinensis
What parasite causes hemoptysis?
Paragonimus westermani
What parasite causes portal hypertension?
Schistosoma mansoni
What parasite causes hematuria and bladder cancer?
Schistosoma haematobium
What parasite causes microcytic anemia?
Ancylostoma, Necator
What parasite causes perianal pruritus?
Enterobius