Cancer & Random_Pharm

Question 1

Trastuzamab - MOA?

Answer 1

Monoclonal antibody for HER2/neu, a protein involved in cell proliferation that is over expressed in many breast cancers (& ass’d w/ worse prognosis)

Question 2

______ is the main hormone responsible for the growth & development of malignant breast tumors.

Answer 2

Estrogen

Question 3

Anastrozole - MOA?

Answer 3

Aromatase inhibitor, suppressing the conversion of androgens into estrogen

(aromatase is highly expressed in ovarian tissue & also in small amounts in subcutaneous fat, normal breast tissue, & cancerous breast tissue)

Question 4

Tamoxifen - MOA?

Answer 4

Breast tissue = Estrogen receptor antagonist
– Tx for breast cancer

Endometrium = Estrogen receptor agonist
– may cause endometrial cancer

Cardiovascular tissue = Agonist & pro coagulation effects
– may cause DVT &/or thromboembolism

Question 5

Ketoconazole - MOA?

Answer 5

Weak anti-androgen that decreases synthesis of steroid hormones in gonads & adrenals

Question 6

Flutamide - MOA?

Answer 6

Non-steroid anti-androgen that competes w/ Testosterone & DHT for testosterone receptors

Question 7

Flutamide - Clinical uses?

Answer 7

Tx of prostate cancer in combination w/ GnRH agonists

Question 8

Allopurinol - MOA?

Answer 8

Xanthine oxidase inhibitor used to reduce uric acid production during the breakdown of tumor cells