Genetics

Question 1

Topoisomerase II - function?

Answer 1

Removal of supercoils

Question 2

Helicase - function?

Answer 2

Unwinding of DNA

Question 3

Single Strand Binding Protein (SSBP) - function?

Answer 3

Stabilization of unwound template strand

Question 4

Primase - function?

Answer 4

Synthesis of RNA primer

Primase also called RNA Polymerase

Question 5

DNA Polymerase III - function?

Answer 5

DNA synthesis of leading & lagging strand

Question 6

DNA Polymerase I - function?

Answer 6

Removal of RNA primer & replacement of RNA w/ DNA (proof reading)

(enzyme also called 5’-exonuclease)

Question 7

Which enzyme is also called “5’-exonuclease”?

Answer 7

DNA Polymerase I

removes RNA primer & replaces RNA w/ DNA – proofreading

Question 8

DNA ligase - function?

Answer 8

Joining of Okazaki fragments (lagging strand)

Question 9

What is “Pleiotropy”?

Answer 9

The occurrence of multiple phenotypic manifestations, often in different organ systems, as a result of a single genetic defect

Question 10

What is “Polyploidy”?

Answer 10

When more than 2 complete sets of homologous chromosomes exist w/in an organism or cell

Question 11

What is “Genetic linkage”?

Answer 11

It describes genetic alleles that tend to be inherited jointly, usually because they are located close to one another on the same strand of DNA

Question 12

What is “Imprinting”?

Answer 12

Parental imprinting refers to the preferential transcription of genes from one or another of a homologous pair of chromosomes depending on the parental origin of the chromosome.